20948596

Source:http://linkedlifedata.com/resource/pubmed/id/20948596

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0259419, umls-concept:C0542341
pubmed:dateCreated	2010-10-15
pubmed:abstractText	Caspase-2 is the most evolutionarily conserved of caspase family members, yet its physiological function has remained unclear and is a matter of considerable debate. Newly published data now suggest that caspase-2 is required for cell cycle regulation, repair of damaged DNA, and in suppressing Myc-induced lymphomagenesis. Additionally, loss of Casp2 in mice leads to features of premature ageing. These findings suggest that caspase-2 has non-apoptotic functions in addition to its context-dependent roles in cell death.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101506835
pubmed:status	PubMed-not-MEDLINE
pubmed:issn	1757-594X
pubmed:author	pubmed-author:DorstynLorettaL, pubmed-author:KumarSharadS
pubmed:issnType	Electronic
pubmed:volume	1
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	96
pubmed:year	2009
pubmed:articleTitle	Putative functions of caspase-2.
pubmed:affiliation	Centre for Cancer Biology, SA Pathology Frome Road, Adelaide, SA 5000 Australia.
pubmed:publicationType	Journal Article