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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1991-7-2
|
| pubmed:abstractText |
The effects of recombinant human erythropoietin (rHuEpo) on megakaryocytopoiesis and platelet production were investigated in splenectomized, sham-operated and intact mice. When splenectomized mice were injected with 50 U of rHuEpo daily for 4 d, peripheral platelet counts, megakaryocyte (MK) size and the percentage of mature MK (stage IV MK) increased from 1 to 4 d after the initial rHuEpo injection. The total number of marrow MK colony forming units (CFU-MK) increased from 2 to 4 d after the initial injection. Furthermore, from days 6 to 8, the total number of marrow MK also increased. In addition, when the dose of rHuEpo was increased to 20-200 U per mouse, clear dose responses were detected in platelet counts and MK numbers. When sham-operated and intact mice were injected with rHuEpo, no significant change in platelet numbers was detected. The number of MK, MK size and the number of CFU-MK increased only in spleen, not in bone marrow. Our data indicate that Epo has stimulatory effects on platelet production in vivo, if used in sufficient quantities.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0007-1048
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
76
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
260-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2094328-Animals,
pubmed-meshheading:2094328-Blood Platelets,
pubmed-meshheading:2094328-Bone Marrow,
pubmed-meshheading:2094328-Bone Marrow Cells,
pubmed-meshheading:2094328-Colony-Forming Units Assay,
pubmed-meshheading:2094328-Erythropoietin,
pubmed-meshheading:2094328-Female,
pubmed-meshheading:2094328-Hematocrit,
pubmed-meshheading:2094328-Hematopoiesis,
pubmed-meshheading:2094328-Humans,
pubmed-meshheading:2094328-Iron,
pubmed-meshheading:2094328-Kinetics,
pubmed-meshheading:2094328-Megakaryocytes,
pubmed-meshheading:2094328-Mice,
pubmed-meshheading:2094328-Mice, Inbred Strains,
pubmed-meshheading:2094328-Platelet Count,
pubmed-meshheading:2094328-Recombinant Proteins,
pubmed-meshheading:2094328-Reference Values,
pubmed-meshheading:2094328-Spleen,
pubmed-meshheading:2094328-Splenectomy,
pubmed-meshheading:2094328-Time Factors
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
The effect of high doses of recombinant human erythropoietin on megakaryocytopoiesis and platelet production in splenectomized mice.
|
| pubmed:affiliation |
First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
|
| pubmed:publicationType |
Journal Article
|