Linked Life Data

20943248

Source:http://linkedlifedata.com/resource/pubmed/id/20943248

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-11-8
pubmed:abstractText
Contaminants including flame retardants, antimicrobial agents and phthalates, occurring as residues in human tissues were associated with altered endocrine function. In our study we analysed the flame retardants tetrabromobisphenol A (TBBPA), hexabromocyclodecane (HBCD), penta-bromodiphenylether (BDE-100) and hexa-BDE (BDE-155), the antimicrobial compounds triclosan (TCS) and triclocarban (TCC) and eight phthalates for their androgenic and antiandrogenic activity in vitro in the MDA-kb2 cell line. No or only weak androgenic activity was observed for all the tested compounds. TBBPA showed weak antiandrogenic activity, which was demonstrated for the first time. The flame retardants HBCD, BDE-100 and BDE-155 enhanced the dihydrotestosterone-dependent activation of androgen receptor-responsive gene expression but exhibited little or no agonistic activity. The enhancement reached 150%, which was similar to the antimicrobials (TCS up to 180%, and TCC up to 130%). This enhancement of androgenic activity represents a novel mode of action of the endocrine activity of flame retardants. In contrast, most phthalates showed antiandrogenic activity. Butylbenzyl phthalate (BBP), dibutyl phthalate (DBP) and diethyl phthalate (DEP) showed strong antiandrogenicity, whereas the action of diethylhexyl phthalate (DEHP), dipentyl phthalate (DPP), dimethyl phthalate (DMP), and the DEHP metabolite monoethylhexyl phthalate (MEHP) was lower. Our in vitro study demonstrates for the first time a weak antiandrogenic activity of TBBPA, and a significant enhancement of the androgenic activity of HBCD, BDE-100 and BDE-155, which represents a novel mechanism of hormonal activity of flame retardants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Androgens, http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents, http://linkedlifedata.com/resource/pubmed/chemical/Carbanilides, http://linkedlifedata.com/resource/pubmed/chemical/Flame Retardants, http://linkedlifedata.com/resource/pubmed/chemical/Hydrocarbons, Brominated, http://linkedlifedata.com/resource/pubmed/chemical/Phthalic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Polybrominated Biphenyls, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Androgen, http://linkedlifedata.com/resource/pubmed/chemical/Triclosan, http://linkedlifedata.com/resource/pubmed/chemical/hexabromocyclododecane, http://linkedlifedata.com/resource/pubmed/chemical/pentabrominated diphenyl ether 100, http://linkedlifedata.com/resource/pubmed/chemical/phthalic acid, http://linkedlifedata.com/resource/pubmed/chemical/tetrabromobisphenol A, http://linkedlifedata.com/resource/pubmed/chemical/triclocarban
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1879-1298
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1245-52
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Some flame retardants and the antimicrobials triclosan and triclocarban enhance the androgenic activity in vitro.
pubmed:affiliation
University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Gründenstrasse 40, CH-4132 Muttenz, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't