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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2011-2-17
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pubmed:abstractText |
Here we present the first paired-end sequencing of tumors from genetically engineered mouse models of cancer to determine how faithfully these models recapitulate the landscape of somatic rearrangements found in human tumors. These were models of Trp53-mutated breast cancer, Brca1- and Brca2-associated hereditary breast cancer, and E-cadherin (Cdh1) mutated lobular breast cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-6914
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pubmed:author |
pubmed-author:AdamsDavid JDJ,
pubmed-author:CampbellPeter JPJ,
pubmed-author:FutrealP AndrewPA,
pubmed-author:GalappaththigeDanushkaD,
pubmed-author:JonkersJosJ,
pubmed-author:KlarenbeekSjoerdS,
pubmed-author:KlijnChristiaanC,
pubmed-author:MudieLaura JLJ,
pubmed-author:SchutEvaE,
pubmed-author:StebbingsLucyL,
pubmed-author:StephensPhillip JPJ,
pubmed-author:StrattonMichael RMR,
pubmed-author:VarelaIgnacioI,
pubmed-author:WesselsLodewyk FaLF,
pubmed-author:van der GuldenHannekeH
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R100
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pubmed:meshHeading |
pubmed-meshheading:20942901-Animals,
pubmed-meshheading:20942901-Animals, Genetically Modified,
pubmed-meshheading:20942901-BRCA1 Protein,
pubmed-meshheading:20942901-BRCA2 Protein,
pubmed-meshheading:20942901-Base Sequence,
pubmed-meshheading:20942901-Breast Neoplasms,
pubmed-meshheading:20942901-Cadherins,
pubmed-meshheading:20942901-Cell Line, Tumor,
pubmed-meshheading:20942901-Female,
pubmed-meshheading:20942901-Gene Fusion,
pubmed-meshheading:20942901-Gene Rearrangement,
pubmed-meshheading:20942901-Genomic Library,
pubmed-meshheading:20942901-Humans,
pubmed-meshheading:20942901-Mice,
pubmed-meshheading:20942901-Mutation,
pubmed-meshheading:20942901-Receptors, LDL,
pubmed-meshheading:20942901-Sequence Deletion,
pubmed-meshheading:20942901-Tumor Suppressor Protein p53,
pubmed-meshheading:20942901-Tumor Suppressor Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Somatic structural rearrangements in genetically engineered mouse mammary tumors.
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pubmed:affiliation |
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK. iv3@sanger.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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