Linked Life Data

20929526

Source:http://linkedlifedata.com/resource/pubmed/id/20929526

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-10-27
pubmed:abstractText
Waldenstrom's Macroglobulinemia is a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a monoclonal immunoglobulin M in the circulation. Recent evidences support the hypothesis that epigenetic modifications lead to Waldesntrom cell proliferation and therefore play a crucial role in the pathogenesis of this disease. Indeed, while cytogenetic and gene expression analysis have demonstrated minimal changes; microRNA aberrations and modification in the histone acetylation status of primary Waldenstrom Macroglobulinemia tumor cells have been described. These findings provide a better understanding of the underlying molecular changes that lead to the initiation and progression of this disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1756-8722
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology.
pubmed:affiliation
Dana-Farber Cancer Institute, Medical Oncology, Harvard Medical School, Boston, MA, USA. aldo_roccaro@dfci.harvard.edu
pubmed:publicationType
Journal Article, Review