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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-23
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pubmed:abstractText |
Several genetic loci (JAZF1, CDC123/CAMK1D, TSPAN8/LGR5, ADAMTS9, VEGFA and HHEX-IDE) were identified to be significantly related to the risk of type 2 diabetes and quantitative metabolic traits in European populations. Here, we aimed to evaluate the impacts of these novel loci on type 2 diabetes risk in a population-based case-control study of Han Chinese (1912 cases and 2041 controls). We genotyped 13 single-nucleotide polymorphisms (SNPs) in/near these genes and examined the differences in allele/genotype frequency between cases and controls. We found that both IDE rs11187007 and HHEX rs1111875 were associated with type 2 diabetes risk (for both variants: odds ratio (OR)=1.15, 95% confidence interval (CI) 1.04-1.28, P=0.009). In a meta-analysis where we pooled our data with the three previous studies conducted in East Asians, we found that the variants of JAZF1 rs864745 (1.09 (1.03-1.16); P=3.49 × 10(-3)) and TSPAN8/LGR5 rs7961581 (1.11(1.05-1.17); P=1.89 × 10(-4)) were significantly associated with type 2 diabetes risk. In addition, the meta-analysis (7207 cases and 8260 controls) also showed that HHEX rs1111875 did have effects on type 2 diabetes in Chinese population (OR=1.15(1.10-1.21); P=1.93 × 10(-8)). This large population-based study and meta-analysis further confirmed the modest effects of the JAZF1, TSPAN8/LGR5 and HHEX-IDE loci on type 2 diabetes in Chinese and other East Asians.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/HHEX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/JAZF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/LGR5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/TSPAN8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tetraspanins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1435-232X
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pubmed:author |
pubmed-author:ChenZhuoZ,
pubmed-author:FengGuo-yinGY,
pubmed-author:HeLinL,
pubmed-author:IngK WKW,
pubmed-author:JayGG,
pubmed-author:KanMeng-yuanMY,
pubmed-author:LiuSi-minSM,
pubmed-author:LiuYunY,
pubmed-author:YangYi-fengYF,
pubmed-author:ZhangDiD,
pubmed-author:ZhangZuo-fengZF,
pubmed-author:ZhaoTengT,
pubmed-author:ZhouDai-zhanDZ
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pubmed:issnType |
Electronic
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
810-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20927120-Aged,
pubmed-meshheading:20927120-Antigens, Neoplasm,
pubmed-meshheading:20927120-Asian Continental Ancestry Group,
pubmed-meshheading:20927120-China,
pubmed-meshheading:20927120-Chromosomes, Human, Pair 10,
pubmed-meshheading:20927120-Chromosomes, Human, Pair 12,
pubmed-meshheading:20927120-Chromosomes, Human, Pair 3,
pubmed-meshheading:20927120-Chromosomes, Human, Pair 6,
pubmed-meshheading:20927120-Chromosomes, Human, Pair 7,
pubmed-meshheading:20927120-Diabetes Mellitus, Type 2,
pubmed-meshheading:20927120-Female,
pubmed-meshheading:20927120-Gene Frequency,
pubmed-meshheading:20927120-Genetic Loci,
pubmed-meshheading:20927120-Genetic Variation,
pubmed-meshheading:20927120-Homeodomain Proteins,
pubmed-meshheading:20927120-Humans,
pubmed-meshheading:20927120-Membrane Glycoproteins,
pubmed-meshheading:20927120-Middle Aged,
pubmed-meshheading:20927120-Neoplasm Proteins,
pubmed-meshheading:20927120-Polymorphism, Single Nucleotide,
pubmed-meshheading:20927120-Receptors, G-Protein-Coupled,
pubmed-meshheading:20927120-Risk,
pubmed-meshheading:20927120-Tetraspanins,
pubmed-meshheading:20927120-Transcription Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese.
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pubmed:affiliation |
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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