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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-12-6
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pubmed:abstractText |
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with no harmful effects toward normal cells or tissues. mda-7/IL-24 was cloned from human melanoma cells by differentiation induction subtraction hybridization (DISH) and promotes endoplasmic reticulum (ER) stress culminating in apoptosis or toxic autophagy in a broad-spectrum of human cancers, when assayed in cell culture, in vivo in human tumor xenograft mouse models and in a Phase I clinical trial in patients with advanced cancers. This therapeutically active cytokine also induces indirect antitumor activity through inhibition of angiogenesis, stimulation of an antitumor immune response, and sensitization of cancer cells to radiation-, chemotherapy- and antibody-induced killing.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/P01 CA104177,
http://linkedlifedata.com/resource/pubmed/grant/P01 CA104177-01A2,
http://linkedlifedata.com/resource/pubmed/grant/P01 CA104177-02,
http://linkedlifedata.com/resource/pubmed/grant/P01 CA104177-03,
http://linkedlifedata.com/resource/pubmed/grant/P01 CA104177-04,
http://linkedlifedata.com/resource/pubmed/grant/P01 CA104177-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA097318,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA097318-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA097318-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA097318-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA097318-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA097318-06A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA097318-07,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA097318-08,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA108520,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA127641,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA127641-01A2,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA127641-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA127641-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA129111-05
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1879-0305
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pubmed:author |
pubmed-author:BarsaJ EJE,
pubmed-author:BhutiaSujit KSK,
pubmed-author:CurielDavid TDT,
pubmed-author:DasSwadesh KSK,
pubmed-author:DashRupeshR,
pubmed-author:DentPaulP,
pubmed-author:DmitrievIgor PIP,
pubmed-author:EmdadLuniL,
pubmed-author:FisherPaul BPB,
pubmed-author:GrantStevenS,
pubmed-author:KegelmenTimothy PTP,
pubmed-author:KimKeetaeK,
pubmed-author:LeeSeok-GeunSG,
pubmed-author:ParkMargaret AMA,
pubmed-author:QuinnBridget ABA,
pubmed-author:RahmaniMohammedM,
pubmed-author:SarkarDevanandD,
pubmed-author:SuZhao-zhongZZ,
pubmed-author:WangXiang-YangXY,
pubmed-author:YacoubAdlyA
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
381-91
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pubmed:dateRevised |
2011-10-3
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.
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pubmed:affiliation |
Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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