| pubmed-article:20921406 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20921406 | lifeskim:mentions | umls-concept:C0034788 | lld:lifeskim |
| pubmed-article:20921406 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:20921406 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:20921406 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:20921406 | lifeskim:mentions | umls-concept:C2926735 | lld:lifeskim |
| pubmed-article:20921406 | pubmed:issue | 42 | lld:pubmed |
| pubmed-article:20921406 | pubmed:dateCreated | 2010-10-20 | lld:pubmed |
| pubmed-article:20921406 | pubmed:abstractText | The early events that determine the decision between lymphocyte tolerance and activation are not well-understood. Using a model of systemic self-antigen recognition by CD4(+) T cells, we show, using single-cell biochemical analyses, that tolerance is characterized by transient signaling events downstream of T-cell receptor engagement in the mammalian target of rapamycin (mTOR) and NF-?B pathways. Parallel studies done by live cell imaging show that the key difference between tolerance and activation is the duration of the T cell-antigen presenting cell (APC) interaction, as revealed by stable T-cell immobilization on antigen encounter. Brief T cell-APC interactions result in tolerance, and prolonged interactions are associated with activation and the development of effector cells. These studies show that the duration of T cell-APC interactions and magnitude of associated TCR-mediated signaling are key determinants of lymphocyte tolerance vs. activation. | lld:pubmed |
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| pubmed-article:20921406 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20921406 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921406 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20921406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20921406 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20921406 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20921406 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:20921406 | pubmed:author | pubmed-author:KrummelMatthe... | lld:pubmed |
| pubmed-article:20921406 | pubmed:author | pubmed-author:NolanGarry... | lld:pubmed |
| pubmed-article:20921406 | pubmed:author | pubmed-author:GalloEugenioE | lld:pubmed |
| pubmed-article:20921406 | pubmed:author | pubmed-author:AbbasAbul KAK | lld:pubmed |
| pubmed-article:20921406 | pubmed:author | pubmed-author:FriedmanRache... | lld:pubmed |
| pubmed-article:20921406 | pubmed:author | pubmed-author:VillarinoAlej... | lld:pubmed |
| pubmed-article:20921406 | pubmed:author | pubmed-author:KatzmanShosha... | lld:pubmed |
| pubmed-article:20921406 | pubmed:author | pubmed-author:O'GormanWilli... | lld:pubmed |
| pubmed-article:20921406 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20921406 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:20921406 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:20921406 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20921406 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20921406 | pubmed:pagination | 18085-90 | lld:pubmed |
| pubmed-article:20921406 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
| pubmed-article:20921406 | pubmed:meshHeading | pubmed-meshheading:20921406... | lld:pubmed |
| pubmed-article:20921406 | pubmed:meshHeading | pubmed-meshheading:20921406... | lld:pubmed |
| pubmed-article:20921406 | pubmed:meshHeading | pubmed-meshheading:20921406... | lld:pubmed |
| pubmed-article:20921406 | pubmed:meshHeading | pubmed-meshheading:20921406... | lld:pubmed |
| pubmed-article:20921406 | pubmed:meshHeading | pubmed-meshheading:20921406... | lld:pubmed |
| pubmed-article:20921406 | pubmed:meshHeading | pubmed-meshheading:20921406... | lld:pubmed |
| pubmed-article:20921406 | pubmed:meshHeading | pubmed-meshheading:20921406... | lld:pubmed |
| pubmed-article:20921406 | pubmed:meshHeading | pubmed-meshheading:20921406... | lld:pubmed |
| pubmed-article:20921406 | pubmed:meshHeading | pubmed-meshheading:20921406... | lld:pubmed |
| pubmed-article:20921406 | pubmed:meshHeading | pubmed-meshheading:20921406... | lld:pubmed |
| pubmed-article:20921406 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20921406 | pubmed:articleTitle | Duration of antigen receptor signaling determines T-cell tolerance or activation. | lld:pubmed |
| pubmed-article:20921406 | pubmed:affiliation | Department of Pathology, University of California, San Francisco, CA 94143, USA. | lld:pubmed |
| pubmed-article:20921406 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20921406 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20921406 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:21473 | entrezgene:pubmed | pubmed-article:20921406 | lld:entrezgene |
