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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
42
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pubmed:dateCreated |
2010-10-20
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pubmed:abstractText |
The early events that determine the decision between lymphocyte tolerance and activation are not well-understood. Using a model of systemic self-antigen recognition by CD4(+) T cells, we show, using single-cell biochemical analyses, that tolerance is characterized by transient signaling events downstream of T-cell receptor engagement in the mammalian target of rapamycin (mTOR) and NF-?B pathways. Parallel studies done by live cell imaging show that the key difference between tolerance and activation is the duration of the T cell-antigen presenting cell (APC) interaction, as revealed by stable T-cell immobilization on antigen encounter. Brief T cell-APC interactions result in tolerance, and prolonged interactions are associated with activation and the development of effector cells. These studies show that the duration of T cell-APC interactions and magnitude of associated TCR-mediated signaling are key determinants of lymphocyte tolerance vs. activation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-11072066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-12086671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-12858171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-14712275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-15466619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-15470046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-15516925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-15924144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-15972626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-16275764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-16287710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-16311599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-16455984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-16533880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-16679021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-17130300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-17277121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-18275834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-19521679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-19542444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-19841171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20921406-19917692
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18085-90
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pubmed:dateRevised |
2011-7-28
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pubmed:meshHeading |
pubmed-meshheading:20921406-Animals,
pubmed-meshheading:20921406-Antigen-Presenting Cells,
pubmed-meshheading:20921406-Flow Cytometry,
pubmed-meshheading:20921406-Immune Tolerance,
pubmed-meshheading:20921406-Lymphocyte Activation,
pubmed-meshheading:20921406-Lymphopenia,
pubmed-meshheading:20921406-Mice,
pubmed-meshheading:20921406-Mice, Inbred BALB C,
pubmed-meshheading:20921406-Receptors, Antigen, T-Cell,
pubmed-meshheading:20921406-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
Duration of antigen receptor signaling determines T-cell tolerance or activation.
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pubmed:affiliation |
Department of Pathology, University of California, San Francisco, CA 94143, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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