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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
49
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pubmed:dateCreated |
2010-11-29
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pubmed:abstractText |
Dysbindin-1 is a 50-kDa coiled-coil-containing protein encoded by the gene DTNBP1 (dystrobrevin-binding protein 1), a candidate genetic factor for schizophrenia. Genetic variations in this gene confer a susceptibility to schizophrenia through a decreased expression of dysbindin-1. It was reported that dysbindin-1 regulates the expression of presynaptic proteins and the release of neurotransmitters. However, the precise functions of dysbindin-1 are largely unknown. Here, we show that dysbindin-1 is a novel nucleocytoplasmic shuttling protein and translocated to the nucleus upon treatment with leptomycin B, an inhibitor of exportin-1/CRM1-mediated nuclear export. Dysbindin-1 harbors a functional nuclear export signal necessary for its nuclear export, and the nucleocytoplasmic shuttling of dysbindin-1 affects its regulation of synapsin I expression. In brains of sandy mice, a dysbindin-1-null strain that displays abnormal behaviors related to schizophrenia, the protein and mRNA levels of synapsin I are decreased. These findings demonstrate that the nucleocytoplasmic shuttling of dysbindin-1 regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DTNBP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Dtnbp1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Karyopherins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Synapsins,
http://linkedlifedata.com/resource/pubmed/chemical/exportin 1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/leptomycin B
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1083-351X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
285
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38630-40
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pubmed:dateRevised |
2011-1-6
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pubmed:meshHeading |
pubmed-meshheading:20921223-Active Transport, Cell Nucleus,
pubmed-meshheading:20921223-Animals,
pubmed-meshheading:20921223-Antibiotics, Antineoplastic,
pubmed-meshheading:20921223-Brain,
pubmed-meshheading:20921223-Carrier Proteins,
pubmed-meshheading:20921223-Cell Nucleus,
pubmed-meshheading:20921223-Cytoplasm,
pubmed-meshheading:20921223-Fatty Acids, Unsaturated,
pubmed-meshheading:20921223-Gene Expression Regulation,
pubmed-meshheading:20921223-HEK293 Cells,
pubmed-meshheading:20921223-Humans,
pubmed-meshheading:20921223-Karyopherins,
pubmed-meshheading:20921223-Mice,
pubmed-meshheading:20921223-Mice, Mutant Strains,
pubmed-meshheading:20921223-Presynaptic Terminals,
pubmed-meshheading:20921223-RNA, Messenger,
pubmed-meshheading:20921223-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:20921223-Schizophrenia,
pubmed-meshheading:20921223-Synapsins
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pubmed:year |
2010
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pubmed:articleTitle |
Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression.
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pubmed:affiliation |
Laboratory of Molecular Neuropathology, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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