Linked Life Data

20890907

Source:http://linkedlifedata.com/resource/pubmed/id/20890907

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-10-26
pubmed:abstractText
Pulse oximetry estimates arterial blood oxygen saturation based on light absorbance of oxy- and deoxy-hemoglobin at 660 and 940 nm wavelengths. Patients with unexpectedly low SpO? often undergo cardio-pulmonary testing to ascertain the cause of their hypoxemia. However, in a subset of patients, a variant hemoglobin is responsible for low SpO? measurements. The extent of this problem is unclear. We performed a systematic literature review for reports of low SpO? associated with variant hemoglobins. We also reviewed unpublished cases from an academic hemoglobin diagnostic reference laboratory. Twenty-five publications and four unpublished cases were identified, representing 45 patients with low SpO? and confirmed variant hemoglobin. Fifty-seven family members of patients had confirmed or suspected variant hemoglobin. Three low oxygen affinity variant hemoglobins had concordantly low SpO? and SaO?. Eleven variant hemoglobins were associated with unexpectedly low SpO? measurements but normal SaO?. Hemoglobin light absorbance testing was reported in three cases, all of which showed abnormal absorption spectra between 600 and 900 nm. Seven other variant hemoglobins had decreased SpO?, with unreported or uncertain SaO?. Twenty-one variant hemoglobins were found to be associated with low SpO?. Most variant hemoglobins were associated with spuriously low SpO?. Abnormal absorption spectra explain the discrepancy between SpO? and SaO(2) for some variants. The differential diagnosis of possible variant hemoglobin ought to be considered in asymptomatic patients found to have unexpectedly low SpO?. The correct diagnosis will help to spare patients from unnecessary investigations and anxiety.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1096-8652
pubmed:author
pubmed:copyrightInfo
© 2010 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
882-5
pubmed:dateRevised
2011-9-1
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Unexpectedly low pulse oximetry measurements associated with variant hemoglobins: a systematic review.
pubmed:affiliation
Section of Hematology and Oncology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. verhovm@mcmaster.ca
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural