Source:http://linkedlifedata.com/resource/pubmed/id/20889359
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2011-1-3
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| pubmed:abstractText |
Fibromyalgia syndrome (FS) frequently co-occurs with regional pain disorders. This study evaluated how these disorders contribute to FS, by assessing effects of local active vs placebo treatment of muscle/joint pain sources on FS symptoms. Female patients with (1) FS+myofascial pain syndromes from trigger points (n=68), or (2) FS+joint pain (n=56) underwent evaluation of myofascial/joint symptoms [number/intensity of pain episodes, pressure pain thresholds at trigger/joint site, paracetamol consumption] and FS symptoms [pain intensity, pressure pain thresholds at tender points, pressure and electrical pain thresholds in skin, subcutis and muscle in a non-painful site]. Patients of both protocols were randomly assigned to two groups [34 each for (1); 28 each for (2)] to receive active or placebo local TrP or joint treatment [injection/hydroelectrophoresis] on days 1 and 4. Evaluations were repeated on days 4 and 8. After therapy, in active--but not placebo-treated-- groups: number and intensity of myofascial/joint episodes and paracetamol consumption decreased and pressure thresholds at trigger/joint increased (p<0.001); FS pain intensity decreased and all thresholds increased progressively in tender points and the non-painful site (p<0.0001). At day 8, all placebo-treated patients requested active local therapy (days 8 and 11) vs only three patients under active treatment. At a 3-week follow-up, FS pain was still lower than basis in patients not undergoing further therapy and had decreased in those undergoing active therapy from day 8 (p<0.0001). Localized muscle/joint pains impact significantly on FS, probably through increased central sensitization by the peripheral input; their systematic identification and treatment are recommended in fibromyalgia.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1532-2149
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
15
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
61-9
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| pubmed:meshHeading |
pubmed-meshheading:20889359-Adolescent,
pubmed-meshheading:20889359-Adult,
pubmed-meshheading:20889359-Aged,
pubmed-meshheading:20889359-Anesthetics, Local,
pubmed-meshheading:20889359-Arthralgia,
pubmed-meshheading:20889359-Comorbidity,
pubmed-meshheading:20889359-Female,
pubmed-meshheading:20889359-Fibromyalgia,
pubmed-meshheading:20889359-Follow-Up Studies,
pubmed-meshheading:20889359-Humans,
pubmed-meshheading:20889359-Middle Aged,
pubmed-meshheading:20889359-Muscle, Skeletal,
pubmed-meshheading:20889359-Myofascial Pain Syndromes,
pubmed-meshheading:20889359-Pain Measurement,
pubmed-meshheading:20889359-Pain Threshold,
pubmed-meshheading:20889359-Severity of Illness Index,
pubmed-meshheading:20889359-Time Factors,
pubmed-meshheading:20889359-Treatment Outcome,
pubmed-meshheading:20889359-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Effects of treatment of peripheral pain generators in fibromyalgia patients.
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| pubmed:affiliation |
Pathophysiology of Pain Laboratory, Ce.S.I., G. D'Annunzio Foundation, Department of Medicine and Science of Aging, Chieti University, via Carlo de Tocco n. 3, Chieti, Italy.
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|