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pubmed-article:2087996pubmed:abstractTextThe effects of metoclopramide (MCP) on Vmax of action potentials of guinea pig papillary muscles were studied with intracellular microelectrodes. MCP 10-550 mumol/L abbreviated the action potential duration at 90% repolarization (APD90) and decreased the maximal rate of rise of action potential (Vmax) dose-dependently. MCP caused rate-dependent and voltage-dependent reductions of Vmax and retardation of the recovery of Vmax. The results present the possible causes of depressant effect of MCP on Na channel.lld:pubmed
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pubmed-article:2087996pubmed:authorpubmed-author:TanTTlld:pubmed
pubmed-article:2087996pubmed:authorpubmed-author:ZhaoG SGSlld:pubmed
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pubmed-article:2087996pubmed:articleTitle[Effects of metoclopramide on Vmax of action potentials in guinea pig papillary muscles].lld:pubmed
pubmed-article:2087996pubmed:affiliationDepartment of Pharmacology, Xi-an Medical University, China.lld:pubmed
pubmed-article:2087996pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2087996pubmed:publicationTypeEnglish Abstractlld:pubmed