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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1991-5-23
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pubmed:abstractText |
The effects of metoclopramide (MCP) on Vmax of action potentials of guinea pig papillary muscles were studied with intracellular microelectrodes. MCP 10-550 mumol/L abbreviated the action potential duration at 90% repolarization (APD90) and decreased the maximal rate of rise of action potential (Vmax) dose-dependently. MCP caused rate-dependent and voltage-dependent reductions of Vmax and retardation of the recovery of Vmax. The results present the possible causes of depressant effect of MCP on Na channel.
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pubmed:language |
chi
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0253-9756
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
229-31
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2087996-Action Potentials,
pubmed-meshheading:2087996-Animals,
pubmed-meshheading:2087996-Anti-Arrhythmia Agents,
pubmed-meshheading:2087996-Dose-Response Relationship, Drug,
pubmed-meshheading:2087996-Female,
pubmed-meshheading:2087996-Guinea Pigs,
pubmed-meshheading:2087996-Male,
pubmed-meshheading:2087996-Metoclopramide,
pubmed-meshheading:2087996-Papillary Muscles
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pubmed:year |
1990
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pubmed:articleTitle |
[Effects of metoclopramide on Vmax of action potentials in guinea pig papillary muscles].
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pubmed:affiliation |
Department of Pharmacology, Xi-an Medical University, China.
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pubmed:publicationType |
Journal Article,
English Abstract
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