Linked Life Data

20879441

Source:http://linkedlifedata.com/resource/pubmed/id/20879441

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 3
pubmed:dateCreated
2010-9-30
pubmed:abstractText
The purpose of this study is to characterize the neuroanatomical variations observed in neurological disorders such as dementia. We do a global statistical analysis of brain anatomy and identify the relevant shape deformation patterns that explain corresponding variations in clinical neuropsychological measures. The motivation is to model the inherent relation between anatomical shape and clinical measures and evaluate its statistical significance. We use Partial Least Squares for the multivariate statistical analysis of the deformation momenta under the Large Deformation Diffeomorphic framework. The statistical methodology extracts pertinent directions in the momenta space and the clinical response space in terms of latent variables. We report the results of this analysis on 313 subjects from the Mild Cognitive Impairment group in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:author
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
529-37
pubmed:dateRevised
2011-2-28
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Multivariate statistical analysis of deformation momenta relating anatomical shape to neuropsychological measures.
pubmed:affiliation
University of Utah, Salt Lake City, UT, USA. nikhil@cs.utah.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural