Linked Life Data

20872245

Source:http://linkedlifedata.com/resource/pubmed/id/20872245

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-12-28
pubmed:abstractText
Peripapillary glial cells (PPGCs) are a peculiar macroglia in avian species, located in the central retina adjacent to the optic nerve head. PPGCs have a similar shape and orientation to Müller cells, which traverse the entire layer of the retina; however, there are differences in protein expression between the two cell types. In the present study, we first demonstrated that PPGCs expressed ?B-crystallin, which is not expressed in Müller cells, during retinal development. ?B-crystallin was first faintly expressed in PPGCs of the E5 retina, adjacent to the optic nerve head. Further, ?B-crystallin was exclusively expressed in PPGCs up to E14. The shape of these cells was bipolar with vitread and ventricular processes. The vitread processes of ?B-crystallin+ PPGCs became finer at E18. Double labeling analysis clearly demonstrated that only vimentin+ or GFAP+ astrocytes were located in the optic nerve head and were demarcated from the retina by ?B-crystallin+ PPGCs. Furthermore, we determined that ?B-crystallin+ PPGCs, with a number of processes, completely wrapped the optic nerve head and were densely located in the junction of the optic nerve head and the retina in a whole mount preparation and in vertical-sectioned retinae. The results of present study, together with reports that retinal astrocytes migrate from the optic nerve head, suggest that PPGCs prevent astrocytes from migrating into the retina in avian species.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1573-6903
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
76-82
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Expression of ?B-crystallin in the peripapillary glial cells of the developing chick retina.
pubmed:affiliation
Department of Anatomy, Chungbuk National University School of Medicine, Cheongju 361-763, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't