|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021081,
umls-concept:C0026809,
umls-concept:C0027651,
umls-concept:C0036525,
umls-concept:C0069717,
umls-concept:C0123759,
umls-concept:C0185117,
umls-concept:C0205195,
umls-concept:C0392756,
umls-concept:C1522484,
umls-concept:C1527249,
umls-concept:C2911684
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2011-2-7
|
|
pubmed:abstractText |
New options are needed for the management and prevention of colorectal cancer liver metastases. Interleukin 12 (IL-12) is an immunostimulatory cytokine with proven antitumour effect in animal models. Despite evidence indicating its biological effect in humans, neither the recombinant protein nor gene therapy vectors expressing IL-12 have shown a relevant benefit in patients with cancer.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1468-3288
|
|
pubmed:author |
pubmed-author:AlzugurenPilarP,
pubmed-author:BerraondoPedroP,
pubmed-author:CrettazJulienJ,
pubmed-author:Gonzalez-AparicioManuelaM,
pubmed-author:Gonzalez-AseguinolazaGloriaG,
pubmed-author:Hernandez-AlcocebaRubenR,
pubmed-author:Hervas-StubbsSandraS,
pubmed-author:ManchenoUxuaU,
pubmed-author:MauleonItsasoI,
pubmed-author:Medina-EcheverzJoseJ,
pubmed-author:PrietoJesusJ
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
60
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
341-9
|
|
pubmed:meshHeading |
pubmed-meshheading:20855451-Animals,
pubmed-meshheading:20855451-Antineoplastic Agents,
pubmed-meshheading:20855451-Colorectal Neoplasms,
pubmed-meshheading:20855451-Combined Modality Therapy,
pubmed-meshheading:20855451-Down-Regulation,
pubmed-meshheading:20855451-Female,
pubmed-meshheading:20855451-Gene Therapy,
pubmed-meshheading:20855451-Genetic Vectors,
pubmed-meshheading:20855451-Immune Tolerance,
pubmed-meshheading:20855451-Interleukin-12,
pubmed-meshheading:20855451-Liver,
pubmed-meshheading:20855451-Liver Neoplasms,
pubmed-meshheading:20855451-Mice,
pubmed-meshheading:20855451-Mice, Inbred C57BL,
pubmed-meshheading:20855451-Mice, Nude,
pubmed-meshheading:20855451-Mifepristone,
pubmed-meshheading:20855451-Organoplatinum Compounds,
pubmed-meshheading:20855451-Transduction, Genetic,
pubmed-meshheading:20855451-Tumor Microenvironment,
pubmed-meshheading:20855451-Xenograft Model Antitumor Assays
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice.
|
|
pubmed:affiliation |
Division of Gene Therapy and Hepatology, CIMA, University of Navarra, Foundation for Applied Medical Research, Pamplona, Spain.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
