Source:http://linkedlifedata.com/resource/pubmed/id/20855212
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
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umls-concept:C1332700,
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umls-concept:C1979963,
umls-concept:C2003903,
umls-concept:C2698650
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| pubmed:issue |
22
|
| pubmed:dateCreated |
2010-10-19
|
| pubmed:abstractText |
Replacement of a secondary amide with a piperidine or azetidine moiety in a series of CCR5 antagonists led to the discovery of compounds with increased intrinsic permeability. This effort led to the identification of a potent CCR5 antagonist which exhibited an improved in vivo pharmacokinetic profile.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1464-3405
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6802-7
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| pubmed:meshHeading | |
| pubmed:year |
2010
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| pubmed:articleTitle |
Evaluation of amide replacements in CCR5 antagonists as a means to increase intrinsic permeability. Part 2: SAR optimization and pharmacokinetic profile of a homologous azacyle series.
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| pubmed:affiliation |
Department of Medicinal Chemistry, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA. jutta.wanner@roche.com
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| pubmed:publicationType |
Journal Article
|