Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2010-11-1
pubmed:abstractText
Oxidative stress caused by hyperglycaemia is believed to be a major molecular mechanism underlying diabetic nephropathy. 2,3,5,4'-tetrahydroxystilbene-2-O-?-d-glucoside (TSG), an active component extract from Polygonum multiflorum Thunb, exhibits antioxidative and anti-inflammatory effects. Possible protective mechanisms of TSG on diabetic nephropathy were investigated in rats and cultured rat mesangial cells. Total cholesterol and triglyceride levels of diabetic rats were clearly increased and these increases were diminished by treatment with TSG. Treatment of diabetic rats with TSG also significantly reduced blood urea nitrogen, creatinine, 24 h urinary protein levels, and kidney weight/body weight. The activities of superoxide dismutase and glutathione peroxidase in renal homogenate were increased markedly, whereas malonaldehyde levels were decreased significantly in TSG-treated diabetic rats. TSG dramatically inhibited diabetes-induced overexpression of TGF-?1 and COX-2, and restored the decrease of SIRT1 expression in diabetic rats. High glucose-induced overexpression of TGF-?1 in cultured mesangial cells was significantly inhibited, whereas the decease of SIRT1 expression was restored by pretreatment of TSG. Nicotinamide, the inhibitor of SIRT1, partially relieved the inhibitory effect of TSG on TGF-?1 expression under high glucose condition. These findings indicate that the protective mechanisms of TSG on diabetic nephropathy are involved in the alleviation of oxidative stress injury and overexpression of COX-2 and TGF-?1, partially via activation of SIRT1.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/2,3,5,4'-tetrahydroxystilbene-2-O-gl..., http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents..., http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants, http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Glucosides, http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Ptgs2 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Sirt1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Sirtuin 1, http://linkedlifedata.com/resource/pubmed/chemical/Stilbenes, http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1879-0712
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
649
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
382-9
pubmed:meshHeading
pubmed-meshheading:20854812-Animals, pubmed-meshheading:20854812-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:20854812-Antioxidants, pubmed-meshheading:20854812-Biological Markers, pubmed-meshheading:20854812-Cell Line, pubmed-meshheading:20854812-Cyclooxygenase 2, pubmed-meshheading:20854812-Diabetic Nephropathies, pubmed-meshheading:20854812-Dose-Response Relationship, Drug, pubmed-meshheading:20854812-Glucosides, pubmed-meshheading:20854812-Histone Deacetylase Inhibitors, pubmed-meshheading:20854812-Hyperglycemia, pubmed-meshheading:20854812-Kidney Cortex, pubmed-meshheading:20854812-Male, pubmed-meshheading:20854812-Mesangial Cells, pubmed-meshheading:20854812-Oxidative Stress, pubmed-meshheading:20854812-Random Allocation, pubmed-meshheading:20854812-Rats, pubmed-meshheading:20854812-Rats, Sprague-Dawley, pubmed-meshheading:20854812-Signal Transduction, pubmed-meshheading:20854812-Sirtuin 1, pubmed-meshheading:20854812-Stilbenes, pubmed-meshheading:20854812-Transforming Growth Factor beta1
pubmed:year
2010
pubmed:articleTitle
Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-?1 pathway.
pubmed:affiliation
Department of Medicine, Medical College, Xianning University, 88 Xianning Road, Xianning 437100, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't