| pubmed-article:2085467 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2085467 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2085467 | lifeskim:mentions | umls-concept:C1366557 | lld:lifeskim |
| pubmed-article:2085467 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:2085467 | lifeskim:mentions | umls-concept:C0072354 | lld:lifeskim |
| pubmed-article:2085467 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2085467 | lifeskim:mentions | umls-concept:C0332325 | lld:lifeskim |
| pubmed-article:2085467 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:2085467 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:2085467 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:2085467 | pubmed:dateCreated | 1991-5-22 | lld:pubmed |
| pubmed-article:2085467 | pubmed:abstractText | A murine keratinocyte cell line that is resistant to the growth-inhibitory effects of transforming growth factor beta 1 (TGF beta 1) was examined for differential gene expression patterns that may be related to the mechanism of the loss of TGF beta 1 responsiveness. Cells that were resistant to the growth-inhibitory effects of TGF beta 1 (KCR cells) were derived from K-ras-transformed BALB/MK keratinocytes (KC cells). Using a subtractive hybridization procedure with KC and KCR mRNAs, we isolated a complementary DNA clone for murine protein disulfide isomerase (PDI). The mRNA for PDI is inhibited by TGF beta 1 treatment in the parental KC cells, but not in the TGF beta 1-resistant KCR cells. Similar PDI down-regulation also occurs in other TGF beta-sensitive cells, but not in a human pancreatic carcinoma cell line which is insensitive to the growth-inhibitory effects of TGF beta 1. The results suggest that misregulation of PDI, an important component of co- and posttranslational modification systems, may be involved in the mechanism by which some cells escape from the growth-inhibitory effects of TGF beta 1. | lld:pubmed |
| pubmed-article:2085467 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2085467 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2085467 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2085467 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2085467 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2085467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2085467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2085467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2085467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2085467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2085467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2085467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2085467 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2085467 | pubmed:month | May | lld:pubmed |
| pubmed-article:2085467 | pubmed:issn | 1044-9523 | lld:pubmed |
| pubmed-article:2085467 | pubmed:author | pubmed-author:MillerD ADA | lld:pubmed |
| pubmed-article:2085467 | pubmed:author | pubmed-author:MosesH LHL | lld:pubmed |
| pubmed-article:2085467 | pubmed:author | pubmed-author:WinklerJ KJK | lld:pubmed |
| pubmed-article:2085467 | pubmed:author | pubmed-author:BascomC CCC | lld:pubmed |
| pubmed-article:2085467 | pubmed:author | pubmed-author:MatrisianL... | lld:pubmed |
| pubmed-article:2085467 | pubmed:author | pubmed-author:SipesN JNJ | lld:pubmed |
| pubmed-article:2085467 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2085467 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:2085467 | pubmed:geneSymbol | c-myc | lld:pubmed |
| pubmed-article:2085467 | pubmed:geneSymbol | K-ras | lld:pubmed |
| pubmed-article:2085467 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2085467 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2085467 | pubmed:pagination | 241-6 | lld:pubmed |
| pubmed-article:2085467 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:2085467 | pubmed:meshHeading | pubmed-meshheading:2085467-... | lld:pubmed |
| pubmed-article:2085467 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2085467 | pubmed:articleTitle | Altered regulation of protein disulfide isomerase in cells resistant to the growth-inhibitory effects of transforming growth factor beta 1. | lld:pubmed |
| pubmed-article:2085467 | pubmed:affiliation | Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232. | lld:pubmed |
| pubmed-article:2085467 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2085467 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2085467 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
