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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1991-5-22
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pubmed:abstractText |
A murine keratinocyte cell line that is resistant to the growth-inhibitory effects of transforming growth factor beta 1 (TGF beta 1) was examined for differential gene expression patterns that may be related to the mechanism of the loss of TGF beta 1 responsiveness. Cells that were resistant to the growth-inhibitory effects of TGF beta 1 (KCR cells) were derived from K-ras-transformed BALB/MK keratinocytes (KC cells). Using a subtractive hybridization procedure with KC and KCR mRNAs, we isolated a complementary DNA clone for murine protein disulfide isomerase (PDI). The mRNA for PDI is inhibited by TGF beta 1 treatment in the parental KC cells, but not in the TGF beta 1-resistant KCR cells. Similar PDI down-regulation also occurs in other TGF beta-sensitive cells, but not in a human pancreatic carcinoma cell line which is insensitive to the growth-inhibitory effects of TGF beta 1. The results suggest that misregulation of PDI, an important component of co- and posttranslational modification systems, may be involved in the mechanism by which some cells escape from the growth-inhibitory effects of TGF beta 1.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1044-9523
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:geneSymbol |
K-ras,
c-myc
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
241-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2085467-Animals,
pubmed-meshheading:2085467-Carcinoma,
pubmed-meshheading:2085467-Cell Division,
pubmed-meshheading:2085467-Cell Line, Transformed,
pubmed-meshheading:2085467-Cell Transformation, Viral,
pubmed-meshheading:2085467-DNA,
pubmed-meshheading:2085467-Drug Resistance,
pubmed-meshheading:2085467-Enzyme Induction,
pubmed-meshheading:2085467-Humans,
pubmed-meshheading:2085467-Isomerases,
pubmed-meshheading:2085467-Keratinocytes,
pubmed-meshheading:2085467-Kirsten murine sarcoma virus,
pubmed-meshheading:2085467-Mice,
pubmed-meshheading:2085467-Neoplasm Proteins,
pubmed-meshheading:2085467-Pancreatic Neoplasms,
pubmed-meshheading:2085467-Protein Disulfide-Isomerases,
pubmed-meshheading:2085467-Protein Processing, Post-Translational,
pubmed-meshheading:2085467-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:2085467-RNA, Messenger,
pubmed-meshheading:2085467-Signal Transduction,
pubmed-meshheading:2085467-Transforming Growth Factor beta,
pubmed-meshheading:2085467-Tumor Cells, Cultured
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pubmed:year |
1990
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pubmed:articleTitle |
Altered regulation of protein disulfide isomerase in cells resistant to the growth-inhibitory effects of transforming growth factor beta 1.
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pubmed:affiliation |
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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