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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0033228,
umls-concept:C0060179,
umls-concept:C0185117,
umls-concept:C0227525,
umls-concept:C0251211,
umls-concept:C1150553,
umls-concept:C1325180,
umls-concept:C1325181,
umls-concept:C1418898,
umls-concept:C1515877,
umls-concept:C1879547,
umls-concept:C2911684
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pubmed:issue |
15-16
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pubmed:dateCreated |
2010-10-11
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pubmed:abstractText |
A lipid-lowering agent, fenofibrate, has been reported to reduce hepatic glucose production and the expression of phosphoenolpyruvate carboxykinase (PEPCK), a rate-limiting enzyme for gluconeogenesis in the liver. However, the precise mechanisms of these effects have remained unclear.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1879-0631
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
9
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
495-500
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20849861-AMP-Activated Protein Kinases,
pubmed-meshheading:20849861-Animals,
pubmed-meshheading:20849861-Carcinoma, Hepatocellular,
pubmed-meshheading:20849861-Cell Line, Tumor,
pubmed-meshheading:20849861-Fenofibrate,
pubmed-meshheading:20849861-Gene Expression Regulation,
pubmed-meshheading:20849861-Glucose,
pubmed-meshheading:20849861-Hepatocytes,
pubmed-meshheading:20849861-Hypolipidemic Agents,
pubmed-meshheading:20849861-Liver,
pubmed-meshheading:20849861-Liver Neoplasms,
pubmed-meshheading:20849861-Male,
pubmed-meshheading:20849861-Mice,
pubmed-meshheading:20849861-Mice, Inbred C3H,
pubmed-meshheading:20849861-Muscle Cells,
pubmed-meshheading:20849861-Phosphoenolpyruvate Carboxykinase (ATP),
pubmed-meshheading:20849861-Phosphorylation,
pubmed-meshheading:20849861-RNA, Messenger,
pubmed-meshheading:20849861-Rats
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pubmed:year |
2010
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pubmed:articleTitle |
Unmetabolized fenofibrate, but not fenofibric acid, activates AMPK and inhibits the expression of phosphoenolpyruvate carboxykinase in hepatocytes.
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pubmed:affiliation |
Department of Cardiology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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