Linked Life Data

2084504

Source:http://linkedlifedata.com/resource/pubmed/id/2084504

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-5-16
pubmed:abstractText
In order to determine whether any structural changes occur in the blood-brain barrier during development which can be related to changes in barrier function over the same period, morphometric methods were used on pieces of visual cortex taken from rats between 16 days gestation and adult and processed for light and electron microscopy. Capillary volume fraction, numbers per unit area, and surface density increased in two phases, before birth and between 10 and 20 days after birth, with no subsequent change after 20 days. Brain parenchymal mitochondria, assumed to be a measure of brain oxidative activity, did not change before birth but increased gradually and continuously after birth from 1.7% to 5.7% in adults. The capillary endothelial mitochondrial volume fraction as a percentage of the endothelial cell cytoplasm, previously thought to be important for ion transport, did not change with age (mean = 5.4%), although there was evidence that mitochondria either divide or change in shape up to 30 days after birth. The endothelial cell thickness decreased with age from 0.6 to 0.2 microns, probably through cell elongation during vascular growth. By combining the data on endothelial mitochondria and vascularity, it was shown that the total endothelial mitochondrial volume per unit length of capillary decreased with age, whereas per unit volume of tissue it increased.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0026-2862
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
412-26
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Cortical microvessels during brain development: a morphometric study in the rat.
pubmed:affiliation
Biomedical Sciences Division, King's College London, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't