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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-9-29
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pubmed:abstractText |
Differentiation-inducing factor-1 (DIF-1) is a putative morphogen that induces cell differentiation in Dictyostelium discoideum. DIF-1 inhibits proliferation of various mammalian tumor cells by suppressing the canonical Wnt/?-catenin signaling pathway. To assess the potential of a novel cancer chemotherapy based on the pharmacological effect of DIF-1, we investigated whether DIF-1 exhibits anti-angiogenic effects in vitro and in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1476-4598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245
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pubmed:meshHeading |
pubmed-meshheading:20843378-Blotting, Western,
pubmed-meshheading:20843378-Cell Line,
pubmed-meshheading:20843378-Cell Movement,
pubmed-meshheading:20843378-Cell Proliferation,
pubmed-meshheading:20843378-Flow Cytometry,
pubmed-meshheading:20843378-Hexanones,
pubmed-meshheading:20843378-Humans,
pubmed-meshheading:20843378-Hydrocarbons, Chlorinated,
pubmed-meshheading:20843378-Immunohistochemistry,
pubmed-meshheading:20843378-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20843378-Signal Transduction,
pubmed-meshheading:20843378-Vascular Endothelial Growth Factor Receptor-2,
pubmed-meshheading:20843378-Wnt Proteins,
pubmed-meshheading:20843378-beta Catenin
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pubmed:year |
2010
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pubmed:articleTitle |
Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/?-catenin signaling pathway.
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pubmed:affiliation |
Department of Clinical Pharmacology, Kyushu University, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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