Linked Life Data

20838432

Source:http://linkedlifedata.com/resource/pubmed/id/20838432

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-9-14
pubmed:abstractText
Malaria remains one of the world's greatest killers and a vaccine is urgently required. There are no established correlates of protection against malaria either for natural immunity to the disease or for immunity conferred by candidate malaria vaccines. The RTS,S/AS02A vaccine offers significant partial efficacy against malaria.mRNA expression of five key cytokines interferon-gamma (IFN-?), monokine induced by gamma (MIG), interleukin-10 (IL-10), transforming growth factor-? (TGF-?) and forkhead box P3 (FoxP3) in peripheral blood mononuclear cells were measured by real-time RT-PCR before and after vaccination with RTS,S/AS02A and Modified Vaccinia virus Ankara encoding the circumsporozoite protein (MVA-CS) in healthy malaria-naïve adult volunteers. The only significant change was in IFN-? mRNA expression, which was increased seven days after vaccination (P ?=? 0.04). Expression of MIG mRNA seven days after vaccination correlated inversely with time to detection of parasites by blood film in an experimental sporozoite challenge (r = 0.94 P ?=? 0.005). An inverse relationship was seen between both TGF-?1 and IL-10 mRNA at baseline and the anti-circumsporozoite IgG antibody response (r ?=? -0.644 P ?=? 0.022 and r =? -0.554 P = 0.031 respectively). This study demonstrates the potential for MIG expression as a correlate of protection against malaria. Baseline levels of the regulatory cytokines TGF-? and IL-10 inversely correlated with antibody levels post vaccination and warrant further studies to improve understanding of individual differences in response to vaccination.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1932-6203
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e12557
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
MIG and the regulatory cytokines IL-10 and TGF-?1 correlate with malaria vaccine immunogenicity and efficacy.
pubmed:affiliation
Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom. susie.dunachie@ndm.ox.ac.uk
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't