Source:http://linkedlifedata.com/resource/pubmed/id/20837075
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
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| pubmed:dateCreated |
2010-11-10
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| pubmed:abstractText |
Programmed cell death-1 (PD-1) plays a critical role in regulating T-cell function during hepatitis B virus (HBV) infection. The present study investigated the relationships between the polymorphisms of the PD-1 gene and the susceptibility to chronic HBV infection. Single nucleotide polymorphisms (SNPs) in PD-1 gene at positions -606G/A (PD-1.1) and +8669 G/A (PD-1.6) were analyzed by bidirectional PCR amplification of specific alleles (Bi-PASA) in 198 chronic HBV patients and 280 controls. Although the genotype and allele frequencies of PD-1.1 were not different between chronic HBV patients and controls, the genotype and allele frequencies of PD-1.6 were significantly different. PD-1.6 GG genotype and the combination of genotypes with G allele were less frequent in HBV patients than in controls (p = 0.007 and p = 0.031, respectively). The allele G was also less frequent in patients than in controls (p = 0.006). Haplotype PD-1.1G/PD-1.6G was less frequent in patients than in controls (p = 0.001). Cirrhosis patients had a lower frequency of PD-1.6 G allele compared with controls (p = 0.007). Our findings, firstly reporting the association between PD-1 polymorphism and HBV infection, suggest that PD-1 gene may be one of the genes predisposing to chronic HBV infection and disease progression.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PDCD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Receptor
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1879-1166
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
71
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1209-13
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:20837075-Adolescent,
pubmed-meshheading:20837075-Adult,
pubmed-meshheading:20837075-Aged,
pubmed-meshheading:20837075-Alleles,
pubmed-meshheading:20837075-Antigens, CD,
pubmed-meshheading:20837075-Apoptosis Regulatory Proteins,
pubmed-meshheading:20837075-Asian Continental Ancestry Group,
pubmed-meshheading:20837075-China,
pubmed-meshheading:20837075-Female,
pubmed-meshheading:20837075-Gene Frequency,
pubmed-meshheading:20837075-Genetic Predisposition to Disease,
pubmed-meshheading:20837075-Genotype,
pubmed-meshheading:20837075-Haplotypes,
pubmed-meshheading:20837075-Hepatitis B, Chronic,
pubmed-meshheading:20837075-Hepatitis B virus,
pubmed-meshheading:20837075-Humans,
pubmed-meshheading:20837075-Male,
pubmed-meshheading:20837075-Middle Aged,
pubmed-meshheading:20837075-Polymorphism, Single Nucleotide,
pubmed-meshheading:20837075-Programmed Cell Death 1 Receptor,
pubmed-meshheading:20837075-Young Adult
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| pubmed:year |
2010
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| pubmed:articleTitle |
Association of polymorphisms of programmed cell death-1 gene with chronic hepatitis B virus infection.
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| pubmed:affiliation |
Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi Province, People's Republic of China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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