Linked Life Data

20825185

Source:http://linkedlifedata.com/resource/pubmed/id/20825185

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
38
pubmed:dateCreated
2010-9-23
pubmed:abstractText
A convenient approach for the high-throughput screening of dendrimer-binding drugs by NMR techniques including saturation transfer difference (STD) NMR and Hadamard-encoded nuclear Overhauser effect measurements is presented. The screening results for insoluble drugs show that phenylbutazone and sulfamethoxazole prefer to localize in the interior pockets of dendrimer, while mycophenolic acid mostly binds on the dendrimer surface, and noncharged insoluble drugs like trimethoprim and primidone do not interact with dendrimers. In another path for soluble drugs, n-butanoic acid and dimethylformamide are screened as dendrimer-binding compounds from a screening pool containing eight soluble compounds by STD NMR. The screening of dendrimer-binding insoluble or soluble compounds can be finished within an hour.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1520-5126
pubmed:author
pubmed:issnType
Electronic
pubmed:day
29
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13182-4
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
High-throughput screening of dendrimer-binding drugs.
pubmed:affiliation
CAS Key Laboratory of Soft Matter Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't