Linked Life Data

20819774

Source:http://linkedlifedata.com/resource/pubmed/id/20819774

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-9-7
pubmed:abstractText
Diet can influence the structural characteristics of both small and large intestine. In this study, we investigated the duodenum and colon of mice fed on genetically modified (GM) soybean during their whole life span (1-24 months) by focusing our attention on the histological and ultrastructural characteristics of the epithelium, the histochemical pattern of goblet cell mucins, and the growth profile of the coliform population. Our results demonstrate that controls and GM-soybean fed mice are similarly affected by ageing. Moreover, the GM soybean-containing diet does not induce structural alterations in duodenal and colonic epithelium or in coliform population, even after a long term intake. On the other hand, the histochemical approach revealed significant diet-related changes in mucin amounts in the duodenum. In particular, the percentage of villous area occupied by acidic and sulpho-mucin granules decreased from controls to GM-fed animals, whereas neutral mucins did not change.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
2038-8306
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e36
pubmed:dateRevised
2011-11-8
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Histochemical and morpho-metrical study of mouse intestine epithelium after a long term diet containing genetically modified soybean.
pubmed:affiliation
Department of Biomolecular Sciences, Clinical Biochemistry Section, University of Urbino, Via Ubaldini 7, Urbino (PU), Italy. serafina.battistelli@uniurb.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't