Linked Life Data

20816399

Source:http://linkedlifedata.com/resource/pubmed/id/20816399

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-9-6
pubmed:abstractText
Notch signaling is an evolutionarily conserved, intercellular signaling mechanism that plays myriad roles during vascular development and physiology in vertebrates. These roles include the regulation of arteriovenous specification and differentiation in both endothelial cells and vascular smooth muscle cells, regulation of blood vessel sprouting and branching during normal and pathological angiogenesis, and the physiological responses of vascular smooth muscle cells. Defects in Notch signaling also cause inherited vascular diseases, such as the degenerative vascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. This review summarizes recent studies that highlight the multiple roles the Notch signaling pathway plays during vascular development and physiology.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1557-8933
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-309
pubmed:dateRevised
2011-5-4
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Notch signaling in the vasculature.
pubmed:affiliation
The Jackson Laboratory, Bar Harbor, ME, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural