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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-9-2
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pubmed:abstractText |
We previously reported increased levels of protein-linked fucosylation with the development of liver cancer and identified many of the proteins containing the altered glycan structures. One such protein is alpha-1-antitrypsin (A1AT). To advance these studies, we performed N-linked glycan analysis on the five major isoforms of A1AT and completed a comprehensive study of the glycosylation of A1AT found in healthy controls, patients with hepatitis C- (HCV) induced liver cirrhosis, and in patients infected with HCV with a diagnosis of hepatocellular carcinoma (HCC).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e12419
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pubmed:meshHeading |
pubmed-meshheading:20811639-Biological Markers,
pubmed-meshheading:20811639-Carcinoma, Hepatocellular,
pubmed-meshheading:20811639-Case-Control Studies,
pubmed-meshheading:20811639-Cohort Studies,
pubmed-meshheading:20811639-Disease Progression,
pubmed-meshheading:20811639-False Positive Reactions,
pubmed-meshheading:20811639-Fucose,
pubmed-meshheading:20811639-Glycosylation,
pubmed-meshheading:20811639-Humans,
pubmed-meshheading:20811639-Lectins,
pubmed-meshheading:20811639-Liver Cirrhosis,
pubmed-meshheading:20811639-Liver Neoplasms,
pubmed-meshheading:20811639-Protein Isoforms,
pubmed-meshheading:20811639-Sensitivity and Specificity,
pubmed-meshheading:20811639-alpha 1-Antitrypsin
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pubmed:year |
2010
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pubmed:articleTitle |
Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma.
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pubmed:affiliation |
Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virus Research, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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