| pubmed-article:20810733 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20810733 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:20810733 | lifeskim:mentions | umls-concept:C0026447 | lld:lifeskim |
| pubmed-article:20810733 | lifeskim:mentions | umls-concept:C0015859 | lld:lifeskim |
| pubmed-article:20810733 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20810733 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:20810733 | lifeskim:mentions | umls-concept:C0475463 | lld:lifeskim |
| pubmed-article:20810733 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:20810733 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:20810733 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:20810733 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:20810733 | lifeskim:mentions | umls-concept:C1548795 | lld:lifeskim |
| pubmed-article:20810733 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:20810733 | pubmed:dateCreated | 2010-10-26 | lld:pubmed |
| pubmed-article:20810733 | pubmed:abstractText | A live attenuated H7N7 candidate vaccine virus was generated by reverse genetics using the modified hemagglutinin (HA) and neuraminidase (NA) genes of highly pathogenic (HP) A/Netherlands/219/03 (NL/03) (H7N7) wild-type (wt) virus and the six internal protein genes of the cold-adapted (ca) A/Ann Arbor/6/60 ca (AA ca) (H2N2) virus. The reassortant H7N7 NL/03 ca vaccine virus was temperature sensitive and attenuated in mice, ferrets, and African green monkeys (AGMs). Intranasal (i.n.) administration of a single dose of the H7N7 NL/03 ca vaccine virus fully protected mice from lethal challenge with homologous and heterologous H7 viruses from Eurasian and North American lineages. Two doses of the H7N7 NL/03 ca vaccine induced neutralizing antibodies in serum and provided complete protection from pulmonary replication of homologous and heterologous wild-type H7 challenge viruses in mice and ferrets. One dose of the H7N7 NL/03 ca vaccine elicited an antibody response in one of three AGMs that was completely protected from pulmonary replication of the homologous wild-type H7 challenge virus. The contribution of CD8(+) and/or CD4(+) T cells to the vaccine-induced protection of mice was evaluated by T-cell depletion; T lymphocytes were not essential for the vaccine-induced protection from lethal challenge with H7 wt viruses. Additionally, passively transferred neutralizing antibody induced by the H7N7 NL/03 ca virus protected mice from lethality following challenge with H7 wt viruses. The safety, immunogenicity, and efficacy of the H7N7 NL/03 ca vaccine virus in mice, ferrets, and AGMs support the evaluation of this vaccine virus in phase I clinical trials. | lld:pubmed |
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| pubmed-article:20810733 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20810733 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20810733 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20810733 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20810733 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20810733 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20810733 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:20810733 | pubmed:author | pubmed-author:SoE MEM | lld:pubmed |
| pubmed-article:20810733 | pubmed:author | pubmed-author:JinHongH | lld:pubmed |
| pubmed-article:20810733 | pubmed:author | pubmed-author:SubbaraoKanta... | lld:pubmed |
| pubmed-article:20810733 | pubmed:author | pubmed-author:KembleGeorgeG | lld:pubmed |
| pubmed-article:20810733 | pubmed:author | pubmed-author:SwayneDavidD | lld:pubmed |
| pubmed-article:20810733 | pubmed:author | pubmed-author:VogelLeatrice... | lld:pubmed |
| pubmed-article:20810733 | pubmed:author | pubmed-author:MatsuokaYumik... | lld:pubmed |
| pubmed-article:20810733 | pubmed:author | pubmed-author:MinJi-YoungJY | lld:pubmed |
| pubmed-article:20810733 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20810733 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:20810733 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20810733 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20810733 | pubmed:pagination | 11950-60 | lld:pubmed |
| pubmed-article:20810733 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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