Source:http://linkedlifedata.com/resource/pubmed/id/20809401
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2010-9-21
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pubmed:abstractText |
Primary progressive aphasia (PPA), typically resulting from a neurodegenerative disease such as frontotemporal lobar degeneration or Alzheimer's disease, is characterized by a progressive loss of specific language functions with relative sparing of other cognitive domains. Three variants of PPA are now recognized: semantic variant, logopenic variant, and nonfluent/agrammatic variant. We discuss recent work characterizing the neurolinguistic, neuropsychological, imaging and pathologic profiles associated with these variants. Improved reliability of diagnoses will be increasingly important as trials for etiology-specific treatments become available. We also discuss the implications of these syndromes for theories of language function.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AG15116,
http://linkedlifedata.com/resource/pubmed/grant/AG17586,
http://linkedlifedata.com/resource/pubmed/grant/AG32953,
http://linkedlifedata.com/resource/pubmed/grant/NS054575,
http://linkedlifedata.com/resource/pubmed/grant/NS44266,
http://linkedlifedata.com/resource/pubmed/grant/NS53488,
http://linkedlifedata.com/resource/pubmed/grant/P01 AG017586-10,
http://linkedlifedata.com/resource/pubmed/grant/P01 AG032953-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG015116-12,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS035867-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS044266-07
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1534-6293
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
484-90
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pubmed:dateRevised |
2011-11-1
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pubmed:meshHeading | |
pubmed:year |
2010
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pubmed:articleTitle |
The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants.
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pubmed:affiliation |
Department of Neurology, 2 Gibson, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA. michafra@mail.med.upenn.edu
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pubmed:publicationType |
Journal Article,
Review,
Research Support, N.I.H., Extramural
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