Source:http://linkedlifedata.com/resource/pubmed/id/20809358
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2011-3-16
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pubmed:abstractText |
Published data on the association between mitogen-activated protein kinase kinase kinase 1 (MAP3K1) gene rs889312 polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength of association between them. A total of seven eligible articles including 26,015 cases and 33,962 controls based on the search criteria were involved in this meta-analysis. We observed that the MAP3K1 rs889312 polymorphism was significantly correlated with breast cancer risk from the fixed effects model when all studies were pooled into the meta-analysis (the allele contrast model: OR 1.09, 95% CI 1.07-1.12; the homozygote codominant: OR 1.22, 95% CI 1.15-1.29; the heterozygote codominant: OR 1.07, 95% CI 1.04-1.11; the dominant model: OR 1.10, 95% CI 1.06-1.13; the recessive model: OR 1.18, 95% CI 1.12-1.25). No significant association was found in the BRCA1 mutation carriers in all genetic models. When stratified by BRCA2 mutation carriers status, statistically significantly elevated risk was found in this meta-analysis (C vs. A: OR 1.12, 95% CI 1.01-1.23; CC vs. AA: OR 1.35, 95% CI 1.06-1.71; the recessive model: OR 1.31, 95% CI 1.05-1.65). There was no evidence for significant association between MAP3K1 rs889312 polymorphism and breast cancer risk in BRCA1 and BRCA2 positive cohort for all comparison models. In conclusion, this meta-analysis suggests that the MAP3K1 rs889312 C allele is a low-penetrant risk factor for developing breast cancer, and there is limited evidence to indicate that MAP3K1 rs889312 polymorphism is associated with increased risk of breast cancer in BRCA1 mutation carriers.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1573-7217
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
663-70
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pubmed:meshHeading |
pubmed-meshheading:20809358-Adolescent,
pubmed-meshheading:20809358-Adult,
pubmed-meshheading:20809358-Aged,
pubmed-meshheading:20809358-Aged, 80 and over,
pubmed-meshheading:20809358-Alleles,
pubmed-meshheading:20809358-Breast Neoplasms,
pubmed-meshheading:20809358-Cohort Studies,
pubmed-meshheading:20809358-DNA Mutational Analysis,
pubmed-meshheading:20809358-Female,
pubmed-meshheading:20809358-Genes, BRCA1,
pubmed-meshheading:20809358-Genetic Predisposition to Disease,
pubmed-meshheading:20809358-Heterozygote,
pubmed-meshheading:20809358-Homozygote,
pubmed-meshheading:20809358-Humans,
pubmed-meshheading:20809358-MAP Kinase Kinase Kinase 1,
pubmed-meshheading:20809358-Middle Aged,
pubmed-meshheading:20809358-Models, Statistical,
pubmed-meshheading:20809358-Odds Ratio,
pubmed-meshheading:20809358-Polymorphism, Genetic,
pubmed-meshheading:20809358-Prognosis,
pubmed-meshheading:20809358-Risk,
pubmed-meshheading:20809358-Sensitivity and Specificity
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pubmed:year |
2011
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pubmed:articleTitle |
Association between mitogen-activated protein kinase kinase kinase 1 rs889312 polymorphism and breast cancer risk: evidence from 59,977 subjects.
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pubmed:affiliation |
Department of General Surgery, Wuxi People's Hospital of Nanjing Medical University, No. 299, Qingyang Road, Wuxi 214023, Jiangsu, China. lphty1_1@yahoo.com.cn
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pubmed:publicationType |
Journal Article,
Meta-Analysis
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