| pubmed-article:20807813 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20807813 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:20807813 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20807813 | lifeskim:mentions | umls-concept:C0870134 | lld:lifeskim |
| pubmed-article:20807813 | lifeskim:mentions | umls-concept:C0812253 | lld:lifeskim |
| pubmed-article:20807813 | lifeskim:mentions | umls-concept:C0229601 | lld:lifeskim |
| pubmed-article:20807813 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:20807813 | lifeskim:mentions | umls-concept:C0686904 | lld:lifeskim |
| pubmed-article:20807813 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:20807813 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:20807813 | pubmed:dateCreated | 2010-9-16 | lld:pubmed |
| pubmed-article:20807813 | pubmed:abstractText | CRKL (CRK-like) is an adapter protein predominantly phosphorylated in cells that express the tyrosine kinase p210(BCR-ABL), the fusion product of a (9;22) chromosomal translocation causative for chronic myeloid leukemia. It has been unclear, however, whether CRKL plays a functional role in p210(BCR-ABL) transformation. Here, we show that CRKL is required for p210(BCR-ABL) to support interleukin-3-independent growth of myeloid progenitor cells and long-term outgrowth of B-lymphoid cells from fetal liver-derived hematopoietic progenitor cells. Furthermore, a synthetic phosphotyrosyl peptide that binds to the CRKL SH2 domain with high affinity blocks association of endogenous CRKL with the p210(BCR-ABL) complex and reduces c-MYC levels in K562 human leukemic cells as well as in mouse hematopoietic cells transformed by p210(BCR-ABL) or the imatinib-resistant mutant T315I. These results indicate that the function of CRKL as an adapter protein is essential for p210(BCR-ABL)-induced transformation. | lld:pubmed |
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| pubmed-article:20807813 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20807813 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20807813 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20807813 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20807813 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20807813 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20807813 | pubmed:issn | 1538-7445 | lld:pubmed |
| pubmed-article:20807813 | pubmed:author | pubmed-author:DrukerBrian... | lld:pubmed |
| pubmed-article:20807813 | pubmed:author | pubmed-author:ImamotoAkiraA | lld:pubmed |
| pubmed-article:20807813 | pubmed:author | pubmed-author:GriswoldIan... | lld:pubmed |
| pubmed-article:20807813 | pubmed:author | pubmed-author:DeiningerMich... | lld:pubmed |
| pubmed-article:20807813 | pubmed:author | pubmed-author:O'HareThomasT | lld:pubmed |
| pubmed-article:20807813 | pubmed:author | pubmed-author:SeoJi-HeuiJH | lld:pubmed |
| pubmed-article:20807813 | pubmed:author | pubmed-author:WoodLisa JLJ | lld:pubmed |
| pubmed-article:20807813 | pubmed:author | pubmed-author:AgarwalAnupri... | lld:pubmed |
| pubmed-article:20807813 | pubmed:author | pubmed-author:ElseaCollin... | lld:pubmed |
| pubmed-article:20807813 | pubmed:copyrightInfo | ©2010 AACR. | lld:pubmed |
| pubmed-article:20807813 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20807813 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20807813 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:20807813 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20807813 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20807813 | pubmed:pagination | 7325-35 | lld:pubmed |
| pubmed-article:20807813 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:20807813 | pubmed:meshHeading | pubmed-meshheading:20807813... | lld:pubmed |
| pubmed-article:20807813 | pubmed:meshHeading | pubmed-meshheading:20807813... | lld:pubmed |
| pubmed-article:20807813 | pubmed:meshHeading | pubmed-meshheading:20807813... | lld:pubmed |
| pubmed-article:20807813 | pubmed:meshHeading | pubmed-meshheading:20807813... | lld:pubmed |
