Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2010-9-16
pubmed:abstractText
CRKL (CRK-like) is an adapter protein predominantly phosphorylated in cells that express the tyrosine kinase p210(BCR-ABL), the fusion product of a (9;22) chromosomal translocation causative for chronic myeloid leukemia. It has been unclear, however, whether CRKL plays a functional role in p210(BCR-ABL) transformation. Here, we show that CRKL is required for p210(BCR-ABL) to support interleukin-3-independent growth of myeloid progenitor cells and long-term outgrowth of B-lymphoid cells from fetal liver-derived hematopoietic progenitor cells. Furthermore, a synthetic phosphotyrosyl peptide that binds to the CRKL SH2 domain with high affinity blocks association of endogenous CRKL with the p210(BCR-ABL) complex and reduces c-MYC levels in K562 human leukemic cells as well as in mouse hematopoietic cells transformed by p210(BCR-ABL) or the imatinib-resistant mutant T315I. These results indicate that the function of CRKL as an adapter protein is essential for p210(BCR-ABL)-induced transformation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-10679091, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-10706883, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-10720695, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-10928987, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-10979976, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-10979977, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-11242111, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-11245441, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-11287972, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-11607838, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-11731788, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-11809706, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-12082638, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-12161751, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-12200353, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-12360279, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-12483533, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-1375394, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-14515252, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-1490392, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-1525828, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-16399079, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-16707466, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-1691092, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-17515907, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-17853901, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-19307307, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-2204061, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-2406902, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-2408044, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-2408149, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-3047582, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-3143116, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-3147434, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-3263566, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-3498165, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-6316147, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-6580527, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-7521685, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-7524758, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-7690960, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-8153630, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-8155767, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-8710363, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-8943867, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-8978305, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-9053848, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-9343435, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-9591773, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-9710592, http://linkedlifedata.com/resource/pubmed/commentcorrection/20807813-9808576
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1538-7445
pubmed:author
pubmed:copyrightInfo
©2010 AACR.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7325-35
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
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