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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-11-30
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pubmed:abstractText |
Class II alleles define the main HLA effect on type 1 diabetes, but there is an independent effect of certain class I alleles. Class II and class I molecules are differently involved in the initiation and effector phases of the immune response, suggesting that class I alleles would be important determinants in the rate of ?-cell destruction. To test this hypothesis we analyzed the role of HLA class I and class II gene polymorphisms in the progression from diabetes-associated autoimmunity to clinical disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3253-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20739684-Age of Onset,
pubmed-meshheading:20739684-Alleles,
pubmed-meshheading:20739684-Autoantibodies,
pubmed-meshheading:20739684-Child,
pubmed-meshheading:20739684-Diabetes Mellitus, Type 1,
pubmed-meshheading:20739684-Disease Progression,
pubmed-meshheading:20739684-Finland,
pubmed-meshheading:20739684-Genotype,
pubmed-meshheading:20739684-HLA-DQ Antigens,
pubmed-meshheading:20739684-HLA-DQ beta-Chains,
pubmed-meshheading:20739684-HLA-DR Antigens,
pubmed-meshheading:20739684-Histocompatibility Antigens Class I,
pubmed-meshheading:20739684-Humans,
pubmed-meshheading:20739684-Infant,
pubmed-meshheading:20739684-Infant, Newborn,
pubmed-meshheading:20739684-Predictive Value of Tests,
pubmed-meshheading:20739684-Risk Assessment
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pubmed:year |
2010
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pubmed:articleTitle |
Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes.
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pubmed:affiliation |
Immunogenetics Laboratory, University of Turku, Turku, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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