Linked Life Data

20732849

Source:http://linkedlifedata.com/resource/pubmed/id/20732849

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-9-7
pubmed:abstractText
A calcipotriol/hydrocortisone combination ointment has been developed for treating psoriasis on sensitive skin areas such as the face. The efficacy and safety of two calcipotriol/hydrocortisone dose combinations were compared with two concentrations of calcipotriol in the same ointment vehicle in patients with psoriasis on the face and body. Patients were randomised to receive 8 weeks once daily treatment with calcipotriol 25 mcg/g or 50 mcg/g, either alone or combined with hydrocortisone 10 mg/g. On the body and face overall, no statistically significant differences in efficacy were observed between the calcipotriol/hydrocortisone formulations versus the calcipotriol alone formulations nor between the two concentrations of calcipotriol (50 mcg/g versus 25 mcg/g). On the face alone, calcipotriol/hydrocortisone was significantly more effective than calcipotriol alone (P < 0.001) but no consistent significant difference was found between the two concentrations of calcipotriol. There was a significant benefit of combining hydrocortisone with calcipotriol in the incidence of adverse drug reactions on the body and face (P = 0.006) and on the face (P < 0.001) but no significant difference was found between the two concentrations of calcipotriol either on the body and face or on the face. In facial psoriasis, combining hydrocortisone with calcipotriol resulted in an improved efficacy and tolerability compared to calcipotriol alone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1167-1122
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
585-9
pubmed:meshHeading
pubmed:articleTitle
Comparison of two different dose combinations of calcipotriol/hydrocortisone ointment used once daily for the treatment of psoriasis vulgaris on the face and body.
pubmed:affiliation
Department of Dermatology, Hôpital de L'Archet, 06202 Nice Cedex 03, France.
pubmed:publicationType
Journal Article, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't