Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1991-4-8
pubmed:abstractText
Use of ciprofloxacin as an alternative to vancomycin for treatment of methicillin-resistant Staphylococcus aureus infection has been paralleled by the emergence of resistant strains. This phenomenon has also been noticed in our hospital. To confirm our observation, methicillin and ciprofloxacin susceptibilities were tested by disk diffusion and broth microdilution techniques. We studied 83 methicillin-resistant Staphylococcus aureus isolates obtained from various sources over a 4-month period. Ciprofloxacin resistance (MIC, greater than 2 micrograms/ml) was detected in 69 isolates (83%). Prior use of ciprofloxacin was reported for 24 of 69 patients with ciprofloxacin-resistant strains and 0 of 14 patients with ciprofloxacin-susceptible strains. The day of detection during the hospital stay and the location of the source patient were not significantly different between resistant and susceptible strains. Bacteriophage typing showed a higher occurrence of nontypeable strains among ciprofloxacin-resistant strains (54%). Review of our microbiology register showed a progressive increase in the rate of resistance to ciprofloxacin during the first year of use, with initial rates being about 10% and recent rates being higher than 80%. On the other hand, methicillin-susceptible S. aureus remained uniformly susceptible to ciprofloxacin (98.4%). We conclude that prior use of ciprofloxacin is an important factor for the selection of ciprofloxacin-resistant strains and that ciprofloxacin has limited usefulness against methicillin-resistant S. aureus.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-170303, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2186669, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2492540, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2549610, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2564067, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2651925, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2675760, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2712546, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2719462, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2729339, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2729953, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2817852, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2891941, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2895133, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2939048, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-2942105, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-3069195, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-3158632, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-3164989, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-3195613, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-3384907, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-3400693, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-3555039, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-3649202, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-3972998, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-6371536, http://linkedlifedata.com/resource/pubmed/commentcorrection/2073096-6436308
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2050-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Ciprofloxacin-resistant methicillin-resistant Staphylococcus aureus in an acute-care hospital.
pubmed:affiliation
Cabrini Medical Center, New York, New York.
pubmed:publicationType
Journal Article