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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-8-26
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pubmed:abstractText |
Homeostatic synaptic scaling alters the strength of synapses to compensate for prolonged changes in network activity and involves both excitatory and inhibitory neurons. The immediate-early gene Narp (neuronal activity-regulated pentraxin) encodes a secreted synaptic protein that can bind to and induce clustering of AMPA receptors (AMPARs). We found that Narp prominently accumulated at excitatory synapses on parvalbumin-expressing interneurons (PV-INs). Increasing network activity resulted in a homeostatic increase of excitatory synaptic strength onto PV-INs that increased inhibitory drive and this response was absent in neurons cultured from Narp-/- mice. Activity-dependent changes in the strength of excitatory inputs on PV-INs in acute hippocampal slices were also dependent on Narp and Narp-/- mice had increased sensitivity to kindling-induced seizures. We propose that Narp recruits AMPARs at excitatory synapses onto PV-INs to rebalance network excitation/inhibition dynamics following episodes of increased circuit activity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-10322495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-10399937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-10526091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-10851171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-10989271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-11734656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-12040056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-12196584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-12684462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-12895424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-1421090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-14735113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-15193778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-15803162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-15820696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-16261181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-16452684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-16763034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-1688284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-16929304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-17088211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-17088213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-17296559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-17610819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-18367087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-18614030,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-19483686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-19729657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-20107060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-20212045,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-2424918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-2565147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-3304536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-7545230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-7619522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-8093417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-8114934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-8786423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-8915675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-9261167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-9651213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-9746136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20729843-9749710
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1546-1726
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1090-7
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20729843-Animals,
pubmed-meshheading:20729843-Mice,
pubmed-meshheading:20729843-Seizures,
pubmed-meshheading:20729843-Neurons,
pubmed-meshheading:20729843-Synapses,
pubmed-meshheading:20729843-Hippocampus,
pubmed-meshheading:20729843-C-Reactive Protein,
pubmed-meshheading:20729843-Cell Membrane,
pubmed-meshheading:20729843-Cells, Cultured,
pubmed-meshheading:20729843-Nerve Tissue Proteins,
pubmed-meshheading:20729843-Extracellular Space,
pubmed-meshheading:20729843-Synaptic Transmission,
pubmed-meshheading:20729843-Presynaptic Terminals,
pubmed-meshheading:20729843-Interneurons
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