| pubmed-article:20729220 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20729220 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:20729220 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:20729220 | lifeskim:mentions | umls-concept:C0041290 | lld:lifeskim |
| pubmed-article:20729220 | lifeskim:mentions | umls-concept:C0022885 | lld:lifeskim |
| pubmed-article:20729220 | lifeskim:mentions | umls-concept:C0392366 | lld:lifeskim |
| pubmed-article:20729220 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:20729220 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:20729220 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:20729220 | pubmed:dateCreated | 2011-5-2 | lld:pubmed |
| pubmed-article:20729220 | pubmed:abstractText | The aim of the present study was to compare the performance of the interferon (IFN)-? tests (QuantiFERON®-TB Gold In-Tube (QFT-G-IT) and T-SPOT®.TB) with the tuberculin skin test (TST) in diagnosing tuberculosis (TB) infection in children, and to analyse discordant results. This was a prospective study including 98 children from contact-tracing studies and 68 children with TST indurations ? 5 mm recruited during public health screenings. Positive IFN-? tests results were associated with risk of exposure (p<0.0001). T-SPOT.TB was positive in 11 (78.6%) out of 14 cases with active TB and QFT-G-IT in nine (64.3%) out of 14 cases. Sensitised T-cells against Mycobacterium avium were detected in six out of 12 children not vaccinated with bacille Calmette-Guérin (BCG), a TST induration 5-9 mm in diameter and both IFN-? tests negative. In concordant IFN-? tests results, a positive correlation was found (p = 0.0001) between the number of responding cells and the amount of IFN-? released. However, in discordant IFN-? tests results this correlation was negative (p = 0.371): an increase in the number of spot-forming cells correlated with a decrease in the amount of IFN-? released. The use of IFN-? tests is helpful for the diagnosis of TB infection, avoiding cross-reactions with BCG immunisation and nontuberculous mycobacterial infections. The analysis of highly discordant results requires further investigation to elucidate possible clinical implications. | lld:pubmed |
| pubmed-article:20729220 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20729220 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729220 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20729220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20729220 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20729220 | pubmed:month | May | lld:pubmed |
| pubmed-article:20729220 | pubmed:issn | 1399-3003 | lld:pubmed |
| pubmed-article:20729220 | pubmed:author | pubmed-author:CantonJJ | lld:pubmed |
| pubmed-article:20729220 | pubmed:author | pubmed-author:SolsonaJJ | lld:pubmed |
| pubmed-article:20729220 | pubmed:author | pubmed-author:DomínguezJJ | lld:pubmed |
| pubmed-article:20729220 | pubmed:author | pubmed-author:AusinaVV | lld:pubmed |
| pubmed-article:20729220 | pubmed:author | pubmed-author:JiménezM AMA | lld:pubmed |
| pubmed-article:20729220 | pubmed:author | pubmed-author:LatorreII | lld:pubmed |
| pubmed-article:20729220 | pubmed:author | pubmed-author:Ruiz-ManzanoJ... | lld:pubmed |
| pubmed-article:20729220 | pubmed:author | pubmed-author:MiláBB | lld:pubmed |
| pubmed-article:20729220 | pubmed:author | pubmed-author:Altet-GómezNN | lld:pubmed |
| pubmed-article:20729220 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:20729220 | pubmed:author | pubmed-author:ZamoraJ JJJ | lld:pubmed |
| pubmed-article:20729220 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20729220 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:20729220 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20729220 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20729220 | pubmed:pagination | 1166-74 | lld:pubmed |
| pubmed-article:20729220 | pubmed:meshHeading | pubmed-meshheading:20729220... | lld:pubmed |
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| pubmed-article:20729220 | pubmed:meshHeading | pubmed-meshheading:20729220... | lld:pubmed |
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| pubmed-article:20729220 | pubmed:meshHeading | pubmed-meshheading:20729220... | lld:pubmed |
| pubmed-article:20729220 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20729220 | pubmed:articleTitle | Diagnosing TB infection in children: analysis of discordances using in vitro tests and the tuberculin skin test. | lld:pubmed |
| pubmed-article:20729220 | pubmed:affiliation | Unitat Clínica de Prevenció i Control de la Tuberculosi de Barcelona, CAP Drassanes, Barcelona, Spain. naltet.bcn.ics@gencat.cat | lld:pubmed |
| pubmed-article:20729220 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20729220 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
