Linked Life Data

20729220

Source:http://linkedlifedata.com/resource/pubmed/id/20729220

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-5-2
pubmed:abstractText
The aim of the present study was to compare the performance of the interferon (IFN)-? tests (QuantiFERON®-TB Gold In-Tube (QFT-G-IT) and T-SPOT®.TB) with the tuberculin skin test (TST) in diagnosing tuberculosis (TB) infection in children, and to analyse discordant results. This was a prospective study including 98 children from contact-tracing studies and 68 children with TST indurations ? 5 mm recruited during public health screenings. Positive IFN-? tests results were associated with risk of exposure (p<0.0001). T-SPOT.TB was positive in 11 (78.6%) out of 14 cases with active TB and QFT-G-IT in nine (64.3%) out of 14 cases. Sensitised T-cells against Mycobacterium avium were detected in six out of 12 children not vaccinated with bacille Calmette-Guérin (BCG), a TST induration 5-9 mm in diameter and both IFN-? tests negative. In concordant IFN-? tests results, a positive correlation was found (p = 0.0001) between the number of responding cells and the amount of IFN-? released. However, in discordant IFN-? tests results this correlation was negative (p = 0.371): an increase in the number of spot-forming cells correlated with a decrease in the amount of IFN-? released. The use of IFN-? tests is helpful for the diagnosis of TB infection, avoiding cross-reactions with BCG immunisation and nontuberculous mycobacterial infections. The analysis of highly discordant results requires further investigation to elucidate possible clinical implications.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1399-3003
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1166-74
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Diagnosing TB infection in children: analysis of discordances using in vitro tests and the tuberculin skin test.
pubmed:affiliation
Unitat Clínica de Prevenció i Control de la Tuberculosi de Barcelona, CAP Drassanes, Barcelona, Spain. naltet.bcn.ics@gencat.cat
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't