Source:http://linkedlifedata.com/resource/pubmed/id/20727935
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2010-11-24
|
| pubmed:abstractText |
Anesthesia is a state of drug-induced unconsciousness with suppression of sensory perception, and consists of both hypnotic and analgesic components. The anesthesiologist monitors the clinical response to noxious stimuli and adjusts drug dosage(s) to achieve an adequate depth of anesthesia, with the aim of reducing operative stress. Acute stress in the perioperative period has four major contributors: anxiety, pain, the surgical stress response, and the potential neurotoxicity of anesthetic agents. Any or all of these may act deleteriously on multiple systems in the brain and have known significant effects on brain regions such as the hippocampus and the hypothalamic-pituitary-adrenal axis. Perioperative stress on the nervous system and the resultant central nervous system (CNS) changes are likely to be causative for altered behaviors that are seen postoperatively, including chronic pain, posttraumatic stress disorder, and learning difficulties. Improving the ability of the anesthesiologist to control all four components of acute perioperative stress could potentially reduce the negative impact of surgery on the brain. Currently, there is no objective measurement for any of these stressors. The development and application of objective measures for perioperative stressors is the first step towards controlling these risk factors and eliminating or reducing their serious postoperative consequences. In this paper we review known and likely effects of perioperative stressors on brain systems and how they may play a significant role in altered postoperative behaviors. We discuss the role of current (and developing) measures of brain function and their potential for monitoring perioperative stress, with an emphasis on functional neuroimaging.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1873-5118
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
92
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
601-12
|
| pubmed:meshHeading |
pubmed-meshheading:20727935-Anesthesia,
pubmed-meshheading:20727935-Anesthetics,
pubmed-meshheading:20727935-Animals,
pubmed-meshheading:20727935-Anxiety,
pubmed-meshheading:20727935-Brain Mapping,
pubmed-meshheading:20727935-Central Nervous System,
pubmed-meshheading:20727935-Depression,
pubmed-meshheading:20727935-Diagnostic Imaging,
pubmed-meshheading:20727935-Humans,
pubmed-meshheading:20727935-Neural Pathways,
pubmed-meshheading:20727935-Pain,
pubmed-meshheading:20727935-Postoperative Complications,
pubmed-meshheading:20727935-Postoperative Period,
pubmed-meshheading:20727935-Stress, Physiological
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Anesthesia and perioperative stress: consequences on neural networks and postoperative behaviors.
|
| pubmed:affiliation |
Department of Radiology and Psychiatry, Children's Hospital Boston, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. dborsook@partners.org
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|