|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2010-9-9
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Melanoma vaccines have not been optimized. Adjuvants are added to activate dendritic cells (DCs) and to induce a favourable immunologic milieu, however, little is known about their cellular and molecular effects in human skin. We hypothesized that a vaccine in incomplete Freund's adjuvant (IFA) would increase dermal Th1 and Tc1-lymphocytes and mature DCs, but that repeated vaccination may increase regulatory cells.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1479-5876
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
79
|
|
pubmed:dateRevised |
2011-10-20
|
|
pubmed:meshHeading |
pubmed-meshheading:20727190-Adjuvants, Immunologic,
pubmed-meshheading:20727190-Cancer Vaccines,
pubmed-meshheading:20727190-Cell Differentiation,
pubmed-meshheading:20727190-Dendritic Cells,
pubmed-meshheading:20727190-Eosinophils,
pubmed-meshheading:20727190-Female,
pubmed-meshheading:20727190-Forkhead Transcription Factors,
pubmed-meshheading:20727190-Humans,
pubmed-meshheading:20727190-Immunophenotyping,
pubmed-meshheading:20727190-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:20727190-Male,
pubmed-meshheading:20727190-Melanoma,
pubmed-meshheading:20727190-Middle Aged,
pubmed-meshheading:20727190-Skin Neoplasms,
pubmed-meshheading:20727190-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:20727190-Time Factors,
pubmed-meshheading:20727190-Vaccination
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Dynamic changes in cellular infiltrates with repeated cutaneous vaccination: a histologic and immunophenotypic analysis.
|
|
pubmed:affiliation |
Human Immune Therapy Center, University of Virginia, Charlottesville, VA, USA.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
