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pubmed-article:20723202pubmed:abstractTextHematopoietic chimerism induces transplantation tolerance across allogeneic and xenogeneic barriers, but has been difficult to achieve in the pig-to-primate model. We have now utilized swine with knockout of the gene coding for alpha-1,3-galactosyltransferase (GalT-KO pigs) as bone marrow donors in an attempt to achieve chimerism and tolerance by avoiding the effects of natural antibodies to Gal determinants on pig hematopoietic cells.lld:pubmed
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pubmed-article:20723202pubmed:copyrightInfo(c) 2010 John Wiley & Sons A/S.lld:pubmed
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pubmed-article:20723202pubmed:articleTitleOccurrence of specific humoral non-responsiveness to swine antigens following administration of GalT-KO bone marrow to baboons.lld:pubmed
pubmed-article:20723202pubmed:affiliationTransplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.lld:pubmed
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