Source:http://linkedlifedata.com/resource/pubmed/id/20717909
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2010-11-24
|
| pubmed:abstractText |
Aspiration is a suspected cause of chronic respiratory disease in infants. We assessed the probability of aspiration by immunocytochemical staining of alveolar macrophages for milk proteins (?-lactalbumin and ?-lactoglobulin) and compared these findings with the Oil-Red-O staining score. Broncho-alveolar lavage (BAL), 24-hr esophageal pH-measurement and/or gastro-esophageal scintigraphy were performed in 111 children. Seventy-nine patients were enrolled. Ten exclusively soya milk formula fed children served as a control group. Individual scores, expressed as the mean percentage of positive staining macrophages counted by three blinded authors were made. Relying on the control group, a positive score was defined as a value higher than 1%. A positive score was found in 26% (18/69). Forty-four percent (8/18) of them had positive gastro-esophageal reflux (GER) tests. In 61% (11/18) a concomitant diagnosis of laryngo-/tracheomalacia was made. A positive score was found in 48% (11/23) of patients with laryngo-/tracheomalacia, compared to 15% (7/46) in infants with normal laryngeal and tracheal anatomy. No correlation was found between the immunocytochemical staining score for milk proteins and the Oil-Red-O staining score. We conclude that assuming the 1% criterion, persistent respiratory symptoms were associated with a positive immunostaining score, suggestive for aspiration, in 26% of infants, in 48% in case of concomitant laryngo- and/or tracheomalacia and in 15% of infants with normal laryngeal and tracheal anatomy. No correlation was found between the immunocytochemical staining score for cow milk proteins and the Oil-Red-O staining score.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1099-0496
|
| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Wiley-Liss, Inc.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1213-9
|
| pubmed:meshHeading |
pubmed-meshheading:20717909-Azo Compounds,
pubmed-meshheading:20717909-Bronchoalveolar Lavage,
pubmed-meshheading:20717909-Bronchoscopy,
pubmed-meshheading:20717909-Case-Control Studies,
pubmed-meshheading:20717909-Child, Preschool,
pubmed-meshheading:20717909-Esophageal pH Monitoring,
pubmed-meshheading:20717909-Esophagus,
pubmed-meshheading:20717909-Female,
pubmed-meshheading:20717909-Gastroesophageal Reflux,
pubmed-meshheading:20717909-Humans,
pubmed-meshheading:20717909-Infant,
pubmed-meshheading:20717909-Infant, Newborn,
pubmed-meshheading:20717909-Lactalbumin,
pubmed-meshheading:20717909-Lactoglobulins,
pubmed-meshheading:20717909-Laryngomalacia,
pubmed-meshheading:20717909-Macrophages,
pubmed-meshheading:20717909-Male,
pubmed-meshheading:20717909-Pulmonary Alveoli,
pubmed-meshheading:20717909-Respiratory Aspiration,
pubmed-meshheading:20717909-Staining and Labeling,
pubmed-meshheading:20717909-Stomach,
pubmed-meshheading:20717909-Tracheomalacia
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Milk protein and Oil-Red-O staining of alveolar macrophages in chronic respiratory disease of infancy.
|
| pubmed:affiliation |
Department of Pediatric Pulmonology, Ghent University Hospital, Ghent, Belgium. frans.debaets@ugent.be
|
| pubmed:publicationType |
Journal Article
|