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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-12-2
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pubmed:abstractText |
Asbestos induces DNA and chromosomal damage, but the DNA repair pathways protecting human cells against its genotoxicity are largely unknown. Polymorphisms in XRCC1 have been associated with altered susceptibility to asbestos-related diseases. However, it is unclear whether oxidative DNA damage repaired by XRCC1 contributes to asbestos-induced chromosomal damage.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1552-9924
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1707-13
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pubmed:dateRevised |
2011-11-1
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pubmed:meshHeading |
pubmed-meshheading:20705543-Asbestos, Amphibole,
pubmed-meshheading:20705543-Asbestos, Crocidolite,
pubmed-meshheading:20705543-Carcinogens,
pubmed-meshheading:20705543-Cell Line,
pubmed-meshheading:20705543-DNA Damage,
pubmed-meshheading:20705543-DNA Repair,
pubmed-meshheading:20705543-DNA-Binding Proteins,
pubmed-meshheading:20705543-Humans,
pubmed-meshheading:20705543-Lung,
pubmed-meshheading:20705543-Mutagenicity Tests,
pubmed-meshheading:20705543-Mutagens,
pubmed-meshheading:20705543-Respiratory Mucosa
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pubmed:year |
2010
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pubmed:articleTitle |
XRCC1 deficiency sensitizes human lung epithelial cells to genotoxicity by crocidolite asbestos and Libby amphibole.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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