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pubmed-article:20694486pubmed:abstractTextIn Alzheimer disease, CSF biomarkers and nuclear imaging are of particular interest. Many studies investigated only one technique, limiting comparison. Here, in 76 patients blinded 99mTc-SPECT was compared to CSF. Sensitivity of CSF was 92%; and 51% for SPECT. Specificity favored SPECT (90 vs. 80%). Both techniques showed no coherence (p = 0.17-0.47). Our results confirm that CSF biomarkers show higher sensitivity. SPECT has higher specificity and can also be used for other dementias without established CSF biomarkers.lld:pubmed
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pubmed-article:20694486pubmed:articleTitleConfirmation rate of blinded (99m)Tc-SPECT compared to neurochemical dementia biomarkers in CSF in patients with Alzheimer disease.lld:pubmed
pubmed-article:20694486pubmed:affiliationClinical Nuclear Medicine Unit, University of Erlangen-Nurenberg, Erlangen, Germany.lld:pubmed
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