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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
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pubmed:dateCreated |
2010-8-30
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|
pubmed:abstractText |
In Alzheimer disease, CSF biomarkers and nuclear imaging are of particular interest. Many studies investigated only one technique, limiting comparison. Here, in 76 patients blinded 99mTc-SPECT was compared to CSF. Sensitivity of CSF was 92%; and 51% for SPECT. Specificity favored SPECT (90 vs. 80%). Both techniques showed no coherence (p = 0.17-0.47). Our results confirm that CSF biomarkers show higher sensitivity. SPECT has higher specificity and can also be used for other dementias without established CSF biomarkers.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Sep
|
|
pubmed:issn |
1435-1463
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|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1111-4
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pubmed:meshHeading |
pubmed-meshheading:20694486-Aged,
pubmed-meshheading:20694486-Alzheimer Disease,
pubmed-meshheading:20694486-Amyloid beta-Peptides,
pubmed-meshheading:20694486-Apolipoprotein E4,
pubmed-meshheading:20694486-Female,
pubmed-meshheading:20694486-Humans,
pubmed-meshheading:20694486-Male,
pubmed-meshheading:20694486-Middle Aged,
pubmed-meshheading:20694486-Peptide Fragments,
pubmed-meshheading:20694486-Sensitivity and Specificity,
pubmed-meshheading:20694486-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:20694486-tau Proteins
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|
pubmed:year |
2010
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|
pubmed:articleTitle |
Confirmation rate of blinded (99m)Tc-SPECT compared to neurochemical dementia biomarkers in CSF in patients with Alzheimer disease.
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pubmed:affiliation |
Clinical Nuclear Medicine Unit, University of Erlangen-Nurenberg, Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study
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