Linked Life Data

20692241

Source:http://linkedlifedata.com/resource/pubmed/id/20692241

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-9-6
pubmed:abstractText
Although much is known about the cerebral neural plasticity that occurs after deafness, it is unclear how much time is required for its development or what other cortical changes may consequently occur. This study provides a longitudinal assessment of cerebral cortical neural plasticity, as manifested in adult deafened cats. A total of 5 male cats were subjected to whole cortex analysis of glucose metabolic activity via 2-deoxy-2[(18)F] fluoro-D-glucose (FDG) micro-positron emission tomography (PET). The imaging was performed at the baseline state of normal hearing and then at 4, 9, 24, and 33 months after the induction of deafness. We compared glucose metabolism between the normal hearing state and each deafened state by using voxel-based statistical analysis (P<0.005). Significant changes were observed in the primary auditory (A1) and primary visual (V1) cortices. A bilateral metabolic decrease was observed in A1 areas and in temporal auditory fields, the extent of which was significantly increased at Month 9. Then it was declined at Month 24. And finally it was disappeared by Month 33. Auditory cortical plasticity subsequent to deafness was thus demonstrated. Furthermore, a significant metabolic upsurge occurred in bilateral occipital areas at Month 33. This increase, involving bilateral occipital and thalamic areas of V1, suggests compensatory hyperactivity of the visual cortex after deafness.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1872-6240
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
1354
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-90
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Cross-modal and compensatory plasticity in adult deafened cats: a longitudinal PET study.
pubmed:affiliation
Department of Otorhinolaryngology, College of Medicine, Seoul National University, Seoul, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't