rdf:type |
|
lifeskim:mentions |
umls-concept:C0010132,
umls-concept:C0010531,
umls-concept:C0037659,
umls-concept:C0229535,
umls-concept:C0244989,
umls-concept:C1280500,
umls-concept:C1366488,
umls-concept:C1521805,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1707524,
umls-concept:C1710082
|
pubmed:issue |
8
|
pubmed:dateCreated |
2010-9-15
|
pubmed:abstractText |
The Wnt/ß-catenin signalling pathway is involved in tumorigenesis including endocrine tumors. We investigated the Wnt/ß-catenin pathway's modulation by corticotropin-releasing hormone (CRH) and somatostatin or somatotropin release-inhibiting factor (SRIF) in mouse pituitary AtT-20 corticotroph cells. The Wnt/?-catenin signalling pathway was activated by CRH and inhibited by SRIF. We provide evidence that cAMP/PKA signalling is involved affecting the GSK-3? phosphorylation status at phospho-GSK-3? (Ser9), thereby altering ?-catenin degradation downstream. Furthermore, CRH and SRIF showed concordant effects on cell proliferation. Our data demonstrate an important role of the Wnt/?-catenin pathway in the proliferative control of pituitary corticotroph cells and describe a mechanism for its regulation by CRH and SRIF.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenocorticotropic Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix Leucine...,
http://linkedlifedata.com/resource/pubmed/chemical/Corticotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Somatostatin,
http://linkedlifedata.com/resource/pubmed/chemical/Tcf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tcf4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1532-4192
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pubmed:author |
|
pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
797-805
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:20690801-Adrenocorticotropic Hormone,
pubmed-meshheading:20690801-Animals,
pubmed-meshheading:20690801-Basic Helix-Loop-Helix Leucine Zipper Transcription Factors,
pubmed-meshheading:20690801-Cell Division,
pubmed-meshheading:20690801-Cell Nucleus,
pubmed-meshheading:20690801-Corticotropin-Releasing Hormone,
pubmed-meshheading:20690801-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:20690801-DNA-Binding Proteins,
pubmed-meshheading:20690801-Glycogen Synthase Kinase 3,
pubmed-meshheading:20690801-Mice,
pubmed-meshheading:20690801-Pituitary Gland,
pubmed-meshheading:20690801-Rats,
pubmed-meshheading:20690801-Signal Transduction,
pubmed-meshheading:20690801-Somatostatin,
pubmed-meshheading:20690801-Transcription Factors,
pubmed-meshheading:20690801-Wnt Proteins,
pubmed-meshheading:20690801-beta Catenin
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pubmed:year |
2010
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pubmed:articleTitle |
CRH and SRIF have opposite effects on the Wnt/?-catenin signalling pathway through PKA/GSK-3? in corticotroph pituitary cells.
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pubmed:affiliation |
Department of Neurosurgery, University of Erlangen-Nuremberg, Erlangen, Germany.
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pubmed:publicationType |
Journal Article
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