Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-9-15
pubmed:abstractText
The Wnt/ß-catenin signalling pathway is involved in tumorigenesis including endocrine tumors. We investigated the Wnt/ß-catenin pathway's modulation by corticotropin-releasing hormone (CRH) and somatostatin or somatotropin release-inhibiting factor (SRIF) in mouse pituitary AtT-20 corticotroph cells. The Wnt/?-catenin signalling pathway was activated by CRH and inhibited by SRIF. We provide evidence that cAMP/PKA signalling is involved affecting the GSK-3? phosphorylation status at phospho-GSK-3? (Ser9), thereby altering ?-catenin degradation downstream. Furthermore, CRH and SRIF showed concordant effects on cell proliferation. Our data demonstrate an important role of the Wnt/?-catenin pathway in the proliferative control of pituitary corticotroph cells and describe a mechanism for its regulation by CRH and SRIF.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adrenocorticotropic Hormone, http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix Leucine..., http://linkedlifedata.com/resource/pubmed/chemical/Corticotropin-Releasing Hormone, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Somatostatin, http://linkedlifedata.com/resource/pubmed/chemical/Tcf4 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Tcf4 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins, http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin, http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1532-4192
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
797-805
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:20690801-Adrenocorticotropic Hormone, pubmed-meshheading:20690801-Animals, pubmed-meshheading:20690801-Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, pubmed-meshheading:20690801-Cell Division, pubmed-meshheading:20690801-Cell Nucleus, pubmed-meshheading:20690801-Corticotropin-Releasing Hormone, pubmed-meshheading:20690801-Cyclic AMP-Dependent Protein Kinases, pubmed-meshheading:20690801-DNA-Binding Proteins, pubmed-meshheading:20690801-Glycogen Synthase Kinase 3, pubmed-meshheading:20690801-Mice, pubmed-meshheading:20690801-Pituitary Gland, pubmed-meshheading:20690801-Rats, pubmed-meshheading:20690801-Signal Transduction, pubmed-meshheading:20690801-Somatostatin, pubmed-meshheading:20690801-Transcription Factors, pubmed-meshheading:20690801-Wnt Proteins, pubmed-meshheading:20690801-beta Catenin
pubmed:year
2010
pubmed:articleTitle
CRH and SRIF have opposite effects on the Wnt/?-catenin signalling pathway through PKA/GSK-3? in corticotroph pituitary cells.
pubmed:affiliation
Department of Neurosurgery, University of Erlangen-Nuremberg, Erlangen, Germany.
pubmed:publicationType
Journal Article